Nucleus Accumbens Subnuclei Regulate Motivated Behavior via Direct Inhibition and Disinhibition of VTA Dopamine Subpopulations

Yang Hongbin; de Jong Johannes W.; Tak YeEun; Peck James; Bateup Helen S.; Lammel Stephan

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Nucleus Accumbens Subnuclei Regulate Motivated Behavior via Direct Inhibition and Disinhibition of VTA Dopamine Subpopulations

机译：通过直接抑制和解除VTA多巴胺亚群，核心尿尿剂亚核亚核调节动机行为

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Mesolimbic dopamine (DA) neurons play a central role in motivation and reward processing. Although the activity of these mesolimbic DA neurons is controlled by afferent inputs, little is known about the circuits in which they are embedded. Using retrograde tracing, electrophysiology, optogenetics, and behavioral assays, we identify principles of afferent-specific control in the mesolimbic DA system. Neurons in the medial shell subdivision of the nucleus accumbens (NAc) exert direct inhibitory control over two separate populations of mesolimbic DA neurons by activating different GABA receptor subtypes. In contrast, NAc lateral shell neurons mainly synapse onto ventral tegmental area (VTA) GABA neurons, resulting in disinhibition of DA neurons that project back to the NAc lateral shell. Lastly, we establish a critical role for NAc subregion-specific input to the VTA underlying motivated behavior. Collectively, our results suggest a distinction in the incorporation of inhibitory inputs between different subtypes of mesolimbic DA neurons.

机译：培素莫博多巴胺（DA）神经元在动机和奖励处理中起着核心作用。尽管这些胚胎DA神经元的活性由传入输入控制，但是关于它们被嵌入的电路知之甚少。使用逆行跟踪，电生理学，邻接性和行为测定，我们鉴定了培养基DA系统中具有传入特异性控制的原理。通过激活不同的GABA受体亚型，细胞核骨折（NAC）中壳中壳细胞的神经元细胞核（NAC）的细胞分离抑制抑制抑制症。相比之下，NAC横向壳神经元主要突触腹侧特术区（VTA）GABA神经元，导致突出突出的DA神经元突出到NAC侧面壳。最后，我们为NAC子区域特定输入对VTA潜在的动机行为建立了关键作用。统称，我们的结果表明，在不同亚型叶蛋白达神经元的不同亚型之间的抑制意见中的含义的区别。

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《Neuron》 |2018年第2期|共20页
作者
Yang Hongbin; de Jong Johannes W.; Tak YeEun; Peck James; Bateup Helen S.; Lammel Stephan;
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作者单位

Univ Calif Berkeley Dept Mol &

Cell Biol 142 Life Sci Addit 3200 Berkeley CA 94720 USA;

Univ Calif Berkeley Dept Mol &

Cell Biol 142 Life Sci Addit 3200 Berkeley CA 94720 USA;

Univ Calif Berkeley Dept Mol &

Cell Biol 142 Life Sci Addit 3200 Berkeley CA 94720 USA;

Univ Calif Berkeley Dept Mol &

Cell Biol 142 Life Sci Addit 3200 Berkeley CA 94720 USA;

Univ Calif Berkeley Dept Mol &

Cell Biol 142 Life Sci Addit 3200 Berkeley CA 94720 USA;

Univ Calif Berkeley Dept Mol &

Cell Biol 142 Life Sci Addit 3200 Berkeley CA 94720 USA;

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正文语种 eng
中图分类神经病学;
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1. Nucleus Accumbens Subnuclei Regulate Motivated Behavior via Direct Inhibition and Disinhibition of VTA Dopamine Subpopulations [J] . Yang Hongbin, de Jong Johannes W., Tak YeEun, Neuron . 2018,第2期

机译：通过直接抑制和解除VTA多巴胺亚群，核心尿尿剂亚核亚核调节动机行为
2. DOPAMINE SIGNALING IN THE NUCLEUS ACCUMBENS CAN BIDIRECTIONALLY REGULATE ETHANOL SEEKING BEHAVIOR [J] . Budygin Evgeny A., Weiner Jeff L. Alcohol . 2017,第期

机译：细胞核中的多巴胺信号传导可以双向调节乙醇寻求行为
3. BK channels mediate dopamine inhibition of firing in a subpopulation of core nucleus accumbens medium spiny neurons [J] . Xincai Ji, Gilles E. Marti Brain research . 2014,第Null期

机译：BK通道介导伏隔核中核多刺神经元亚群中的多巴胺抑制射击
4. A Subpopulation of Mesencephalic Dopamine Neurons Interfaces the Shell of Nucleus Accumbens and the Dorsolateral Striatum in Rats [C] . Yvette C. van Dongen, Bogdan P. Kolomiets, Henk J. Groenewegen, Triennial Meeting of the International Basal Ganglia Society . 2009

机译：中脑多巴胺神经元的亚群界面嵌入大鼠的核心腺壳和背侧纹状体
5. Examination of the neurochemical and behavioral effects of methamphetamine and amphetamine on dopamine and glutamate in the nucleus accumbens and prefrontal cortex: Putative reasons for the greater popularity of methamphetamine and implications for treatment. [D] . Shoblock, James Richard. 2003

机译：甲基苯丙胺和苯丙胺对伏隔核和前额叶皮层中多巴胺和谷氨酸的神经化学和行为作用的检查：甲基苯丙胺更受欢迎的推定原因及其治疗意义。
6. Nucleus accumbens subnuclei regulate motivated behavior via direct inhibition and disinhibition of VTA dopamine subpopulations [O] . Hongbin Yang, Johannes Willem de Jong, YeEun Tak, -1

机译：伏伏核亚核通过直接抑制和抑制VTA多巴胺亚群来调节动机行为
7. Faculty Opinions recommendation of Nucleus accumbens subnuclei regulate motivated behavior via direct inhibition and disinhibition of VTA dopamine subpopulations. [O] . Luis de Lecea 2018

机译：教师意见核心亚核亚核的推荐通过直接抑制和解除VTA多巴胺亚群调节动机行为。

Nucleus Accumbens Subnuclei Regulate Motivated Behavior via Direct Inhibition and Disinhibition of VTA Dopamine Subpopulations

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