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Estimation of Current and Future Physiological States in Insular Cortex

机译：栗色皮层中当前和未来生理状态的估算

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摘要

Interoception, the sense of internal bodily signals, is essential for physiological homeostasis, cognition, and emotions. While human insular cortex (InsCtx) is implicated in interoception, the cellular and circuit mechanisms remain unclear. We imaged mouse InsCtx neurons during two physiological deficiency states: hunger and thirst. InsCtx ongoing activity patterns reliably tracked the gradual return to homeostasis but not changes in behavior. Accordingly, while artificial induction of hunger or thirst in sated mice via activation of specific hypothalamic neurons (AgRP or SFOGLUT) restored cue-evoked food- or water-seeking, InsCtx ongoing activity continued to reflect physiological satiety. During natural hunger or thirst, food or water cues rapidly and transiently shifted InsCtx population activity to the future satiety-related pattern. During artificial hunger or thirst, food or water cues further shifted activity beyond the current satiety-related pattern. Together with circuit-mapping experiments, these findings suggest that InsCtx integrates visceral-sensory signals of current physiological state with hypothalamus-gated amygdala inputs that signal upcoming ingestion of food or water to compute a prediction of future physiological state.
机译：中断，内部身体信号感，对生理稳态，认知和情绪至关重要。虽然人体蒙塞塞（INSCTX）涉及进入，但蜂窝和电路机构仍然不明朗。在两个生理缺乏状态期间，我们拍摄了小鼠Insctx神经元：饥饿和口渴。 Insctx正在进行的活动模式可靠地跟踪逐渐返回稳态，但行为没有变化。因此，虽然通过激活特定下丘脑神经元（AGRP或Sfoglut）恢复的提示食物或寻求追求的食物或寻求疗法，但尚未反映生理饱腹感染的饥饿小鼠的饥饿或呼吸术中的饥饿或渴望。在自然饥饿或口渴，食物或水提示迅速和瞬时转移到未来饱腹腹期相关的模式。在人造饥饿或渴望期间，食物或水提示进一步转移超出当前饱腹腹筋相关模式的活动。这些研究结果与电路映射实验一起表明，INSCTX将目前生理状态的内脏感觉信号与下丘脑门控杏仁醛输入相结合，即发出即将摄入食物或水来计算未来生理状态的预测。

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  • 来源
    《Neuron》 |2020年第6期|共28页
  • 作者

    Livneh Yoav; Sugden Arthur U.; Madara Joseph C.; Essner Rachel A.; Flores Vanessa I; Sugden Lauren A.; Resch Jon M.; Lowell Bradford B.; Andermann Mark L.;

  • 作者单位

    Harvard Med Sch Beth Israel Deaconess Med Ctr Div Endocrinol Diabet &

    Metab Boston MA 02215 USA;

    Harvard Med Sch Beth Israel Deaconess Med Ctr Div Endocrinol Diabet &

    Metab Boston MA 02215 USA;

    Harvard Med Sch Beth Israel Deaconess Med Ctr Div Endocrinol Diabet &

    Metab Boston MA 02215 USA;

    Harvard Med Sch Beth Israel Deaconess Med Ctr Div Endocrinol Diabet &

    Metab Boston MA 02215 USA;

    Harvard Med Sch Beth Israel Deaconess Med Ctr Div Endocrinol Diabet &

    Metab Boston MA 02215 USA;

    Duquesne Univ Dept Math &

    Comp Sci Pittsburgh PA 15219 USA;

    Harvard Med Sch Beth Israel Deaconess Med Ctr Div Endocrinol Diabet &

    Metab Boston MA 02215 USA;

    Harvard Med Sch Beth Israel Deaconess Med Ctr Div Endocrinol Diabet &

    Metab Boston MA 02215 USA;

    Harvard Med Sch Beth Israel Deaconess Med Ctr Div Endocrinol Diabet &

    Metab Boston MA 02215 USA;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 神经病学;
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