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首页> 外文期刊>Radiation Research: Official Organ of the Radiation Research Society >Dicentric Dose Estimates for Patients Undergoing Radiotherapy in the RTGene Study to Assess Blood Dosimetric Models and the New Bayesian Method for Gradient Exposure
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Dicentric Dose Estimates for Patients Undergoing Radiotherapy in the RTGene Study to Assess Blood Dosimetric Models and the New Bayesian Method for Gradient Exposure

机译：在RTGENE研究中进行放射治疗的患者的Dicentric剂量估计，评估血液剂量模型和新的贝叶斯梯度曝光方法

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摘要

The RTGene study was focused on the development and validation of new transcriptional biomarkers for prediction of individual radiotherapy patient responses to ionizing radiation. In parallel, for validation purposes, this study incorporated conventional biomarkers of radiation exposure, including the dicentric assay. Peripheral blood samples were taken with ethical approval and informed consent from a total of 20 patients undergoing external beam radiotherapy for breast, lung, gastrointestinal or genitourinary tumors. For the dicentric assay, two samples were taken from each patient: prior to radiotherapy and before the final fraction. Blood samples were set up using standard methods for the dicentric assay. All the baseline samples had dicentric frequencies consistent with the expected background for the normal population. For blood taken before the final fraction, all the samples displayed distributions of aberrations, which arc indicative of partial-body exposures. Whole-body and partial-body cytogenetic doses were calculated with reference to a 250-kVp( )X-ray calibration curve and then compared to the dose to blood derived using two newly developed blood dosimetric models. Initial comparisons indicated that the relationship between these measures of dose appear very promising, with a correlation of 0.88 (P = 0.001). A new Bayesian zero-inflated Poisson finite mixture method was applied to the dicentric data, and partial-body dose estimates showed no significant difference (P 0.999) from those calculated by the contaminated Poisson technique. The next step will he further development and validation in a larger patient group. (C) 2018 by Radiation Research Society
机译：RTGENE研究专注于新转录生物标志物的开发和验证，以预测个体放射治疗患者对电离辐射的反应。对于验证目的并行，该研究掺入了常规的辐射曝光生物标志物，包括Dicentric测定。外周血样品采用道德批准，并提供了20名患者进行乳腺癌，肺，胃肠道或泌尿族肿瘤的外梁放射治疗的20名患者的知识同意。对于Dicentric测定，从每个患者中取出两个样品：在放射治疗之前和最终级分之前。使用用于Dicentric测定的标准方法建立血样。所有基线样本都有与正常人群的预期背景一致的Dicentric频率。对于在最终级分之前所采取的血液，所有样品都显示出像差的分布，这是指指示部分身体暴露的弧形。通过参考250 kVP（）X射线校准曲线计算全体和部分体细胞遗传学剂量，然后与使用两个新开发的血液剂量模型进行的剂量与血液的剂量进行比较。初始比较表明，这些剂量措施之间的关系出现非常有前途，其相关性为0.88（p = 0.001）。将新的贝叶斯零充气泊松有限混合物方法应用于DicEntric数据，部分体剂量估计显示出由受污染的泊松技术计算的那些没有显着差异（P> 0.999）。下一步将进一步发展和验证更大的患者组。 （c）2018由辐射研究协会

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