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首页> 外文期刊>Research in autism spectrum disorders >Parental socioeconomic position and risk of autism spectrum disorders in offspring: A cohort study of 9,648 individuals in Denmark 1976-2013
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Parental socioeconomic position and risk of autism spectrum disorders in offspring: A cohort study of 9,648 individuals in Denmark 1976-2013

机译：后代父母社会经济地位与自闭症谱系障碍的风险：1976 - 2013年丹麦9,648人的队列研究

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BackgroundThe results of studies of the association between parental socioeconomic position (SEP) and risk of autism spectrum disorder (ASD) in offspring are inconsistent, perhaps due to contextual differences in health care systems and their influence on risk of ASD diagnosis among different socioeconomic groups. The present study investigated the association between parental SEP in adulthood and risk of ASD diagnosis in offspring in a Nordic welfare state and whether this association was modified by parental childhood SEP. MethodThe study population comprised 9648 live-born singletons who were followed in the Psychiatric Central Register from birth in 1976–1996 until 2013. Cox regression was used to estimate hazard ratios for ASD diagnosis according to parental SEP in adulthood. ResultsThe crude results showed a tendency towards higher parental SEP in adulthood being associated with higher risk of ASD diagnosis in offspring. However, the association was reversed after adjustment for possible confounders. The reversion of the direction of the association was entirely attributable to the strong confounding effect of calendar year. Further, the results showed that parental childhood SEP modified the association between parental SEP in adulthood and risk of ASD diagnosis in offspring. ConclusionsBoth methodological and contextual issues may be of great importance for the observed association between parental SEP and risk of ASD diagnosis in offspring. Particularly, the secular trends in ASD diagnoses seem to be of great importance suggesting that changes in diagnostic patterns may influence the association between parental SEP and risk of being diagnosed with ASD.
机译：背景技术后代父母社会经济地位（SEP）与自闭症谱系障碍（ASD）的风险研究结果不一致，也许是由于医疗保健系统的上下文差异及其对不同社会经济群体之间的ASD诊断风险的影响。本研究调查了在北欧福利状态下的成年期患者在成年期（Asd诊断Asd诊断的风险，以及所述父母儿童SEP的修饰。方法包括1976年至1996年出生的精神病中央登记术中的9648名活生生的单身人士，直到2013年。Cox回归用于估算ASD诊断的危险比，根据成年期间的父母SEP。结果原油结果表明，成年期患者在成年期与后代ASD诊断风险较高有关。但是，在调整可能的混乱后，该关联在调整后逆转。协会方向的逆转完全归因于日历年的强烈混杂效果。此外，结果表明，家育儿童SEP修饰了成年期间患病的关联，以及后代诊断的风险。结论博学方法论和背景问题可能对观察到的父母SEP和后代诊断风险的关联具有重要意义。特别是，ASD诊断的世俗趋势似乎具有重要意义，表明诊断模式的变化可能影响父母的血症之间的关联和被诊断为ASD的风险。

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