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首页> 外文期刊>Retinal cases & brief reports >IMMUNE RETINOPATHY ASSOCIATED WITH NIVOLUMAB ADMINISTRATION FOR METASTATIC NON-SMALL CELL LUNG CANCER
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IMMUNE RETINOPATHY ASSOCIATED WITH NIVOLUMAB ADMINISTRATION FOR METASTATIC NON-SMALL CELL LUNG CANCER

机译：免疫视网膜疗法与Nivolumab施用转移性非小细胞肺癌

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摘要

Purpose: To present a novel case of immune retinopathy associated with nivolumab therapy for non-small cell lung cancer. Methods: Retrospective chart review. Results: A 64-year-old woman presented with photoreceptor injury evidenced by hypoautofluorescent and hyperautofluorescent patches on fundus autofluorescence, loss of the ellipsoid zone on optical coherence tomography, and dysfunction of the rods and cones on electroretinogram. She had a history of Stage IV lung adenocarcinoma, treated with nivolumab, a checkpoint inhibitor. Serology testing was negative for paraneoplastic antibody panel, antirecoverin and antienolase antibodies, but positive for antiretinal antibodies against 30-kDa (carbonic anhydrase II), 35-kDa (GADPH), 38-kDA, 58-kDa (PKM2), and 112-kDa proteins. Cessation of the medication and high-dose oral steroids resulted in resolution of her symptoms and stability of ocular findings. Conclusion: The checkpoint inhibitors, including nivolumab, have significant ocular side effects. All patients receiving nivolumab should undergo a baseline comprehensive eye examination and should be counseled to seek medical attention immediately if visual changes occur.
机译：目的：提出与非小细胞肺癌的Nivolumab疗法相关的一种小巧的免疫视网膜病变。方法：回顾性图表审查。结果：一名64岁女性患有光感受器损伤，由低荧光和高荧光斑件证明对眼底自发荧光，光学相干断层扫描上的椭圆形区的丧失，以及杆和电气图孔的功能障碍。她患有阶段IV肺腺癌，用Nivolumab治疗，检查点抑制剂。血管蛋白抗体面板，反释塞蛋白和抗毒素酶抗体是阴性的阴性，但对30-KDA（碳酸酐酶II），35-KDA（GADPH），38-KDA，58-KDA（PKM2）和112℃的反向抗体阳性KDA蛋白。药物和高剂量口服类固醇的停止导致了她的症状和眼镜发现的症状和稳定性。结论：检查点抑制剂（包括Nivolumab）具有显着的眼睛副作用。所有接受Nivolumab的患者应经历基线综合眼科检查，如果发生视觉变化，应咨询以立即寻求医疗注意力。

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