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Central Nervous System Infections Associated with Immunosuppressive Therapy for Rheumatic Disease

机译:中枢神经系统感染与免疫抑制治疗有关的风湿病

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摘要

Patients on immunosuppressive therapy for rheumatic diseases are at increased risk of infection. Although infections of the central nervous system (CNS) are less common compared with other sites, patients on broadly immunosuppressive and biologic immunomodulatory agents may be susceptible to more severe, disseminated forms of infection, including of the CNS. Certain key principles regarding infection risk apply across immunosuppressive therapies, including increased risk with higher doses and longer duration of therapy and with combination therapy. Providers should be aware of the CNS infection risk related to immunosuppressant use to help guide best practices for screening and prophylaxis.
机译:免疫抑制患者的风湿病患者增加了感染风险。 尽管中枢神经系统(CNS)的感染与其他部位相比不太常见,但是患者宽恕的患者患者可能易于更严重,散发形式的感染形式,包括CNS。 关于感染风险的某些关键原理适用于免疫抑制疗法,包括较高剂量和较长的治疗持续时间和组合治疗的风险增加。 提供商应了解与免疫抑制剂的CNS感染风险,用于帮助指导筛选和预防的最佳实践。

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