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首页> 外文期刊>Russian journal of genetics >Study of the Individual Radiosensitivity in Humans Based on the Assessment of the Frequency of Chromosome Aberrations and Micronuclei in Peripheral Blood T Lymphocytes
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Study of the Individual Radiosensitivity in Humans Based on the Assessment of the Frequency of Chromosome Aberrations and Micronuclei in Peripheral Blood T Lymphocytes

机译：基于对外周血T淋巴细胞染色体畸变和微核频率评估的基于评估人类的个体放射敏感性研究

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摘要

The influence of low-dose ionizing radiation on a human being is increasing in the modern world (medical diagnostics etc.). The issue of the effect of low-doses on human health is topical and controversial. It is known that in the population up to 15% of people react to radiation exposure differently from what has been expected, which, according to the published data, happens owing to their genome peculiarities. The objective of the current study was to investigate the influence of chronic lowdose rate exposure (doses to red bone marrow varied within the range 3-4600 mGy) of the Techa River residents (South Urals) on the radiosensitivity of T cells in vivo and in vitro under additional gamma exposure of peripheral blood T lymphocytes (0.5, 1, and 2 Gy). Such cytogenetic parameters as frequency of unstable chromosome aberrations and micronuclei were used as irradiation markers. Persons were considered radiosensitive if the obtained values of the analyzed parameters for them exceeded the 90% percentile. On the basis of the findings of the performed study, the following conclusions were drawn: about 10% of donors demonstrated increased radiosensitivity; moreover, the effect did not depend on the dose of chronic exposure; no age dependence of radiosensitivity in the studied age range (49-89 years) of the donors was revealed. In most cases, we did not detect a reproducible radiosensitivity effect in the same donor under different irradiation regimes.
机译：低剂量电离辐射对现代世界（医学诊断等）的影响。低剂量对人类健康影响的问题是局部和争议。众所周知，在最多15％的人口中，与预期的辐射暴露的人口相差，根据已发表的数据，这是由于其基因组特异性发生的情况。目前的研究目的是探讨慢性低糖率暴露（剂量在3-4600 MGY范围内）的慢性低糖率暴露（南乌拉尔在3-4600 MGY范围内变化）对体内T细胞的放射敏感性在额外的γ暴露外周血T淋巴细胞（0.5,1和2 GY）的体外。这种细胞遗传学参数作为不稳定染色体畸变和微核的频率被用作辐照标记。如果所获得的分析参数的值超过90％百分位数，则被认为是放射敏感性的。在进行所进行研究的结果的基础上，得出了以下结论：约10％的捐助者证明了放射敏感性增加;此外，效果不依赖于慢性暴露剂量;揭示了学习年龄范围（49-89岁）在捐助者的辐射敏感度的年龄依赖性。在大多数情况下，我们在不同的照射制度下没有检测到同一供体中的可重复的放射敏感效果。

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