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首页> 外文期刊>Oncology: International Journal of Cancer Research and Treatment >Monitoring of Serum Carcinoembryonic Antigen Levels after Curative Resection of Colon Cancer: Cutoff Values Determined according to Preoperative Levels Enhance the Diagnostic Accuracy for Recurrence
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Monitoring of Serum Carcinoembryonic Antigen Levels after Curative Resection of Colon Cancer: Cutoff Values Determined according to Preoperative Levels Enhance the Diagnostic Accuracy for Recurrence

机译：在结肠癌治疗切除后监测血清癌胚抗原水平：根据术前水平确定的截止值提高了复发的诊断准确性

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Objectives: Serum carcinoembryonic antigen (CEA) has been widely used for postoperative surveillance for colorectal cancer. However, serum CEA has a poor diagnostic accuracy for detecting recurrence. We tested the hypothesis that determining cutoff values according to the preoperative serum CEA levels would enhance the diagnostic accuracy. Methods: Serum CEA was measured before and 1-6 months after surgery in 783 patients with curatively resected colon cancer from 2005 through 2013. The cutoff values during surveillance were determined separately according to preoperative serum CEA levels. Results: In patients with negative preoperative serum CEA, the diagnostic accuracy for recurrence was 89.1% when a postoperative cutoff value was set at 5 ng/mL. However, in patients with positive preoperative serum CEA, the diagnostic accuracy was 58.4% when a postoperative cutoff value was set at 5 ng/mL, and was 75.6% when a cutoff value was set at 8 ng/mL. Among patients with positive preoperative serum CEA, the recurrence-free survival rate was significantly lower in patients with a serum CEA of >= 8 ng/mL than those with a serum CEA of <8 ng/mL (p = 0.0018). Conclusions: The diagnostic accuracy of serum CEA for recurrence is enhanced by separately setting cutoff values according to preoperative serum CEA. (C) 2017 The Author(s) Published by S. Karger AG, Basel
机译：目的：血清癌胚抗原（CEA）已广泛用于结直肠癌的术后监测。然而，血清CEA具有较差的诊断准确性，用于检测复发。我们测试了根据术前血清CEA水平确定截止值的假设将提高诊断准确性。方法：在2005年至2013年之前，在783例治疗结肠癌患者的手术前和1-6个月之前测量血清CEA。根据术前血清CEA水平分别测定监测期间的截止值。结果：当术后截止值设定为5 ng / ml时，在负术前血清CEA的患者中，复发的诊断准确性为89.1％。然而，当术后截止值设定为5ng / ml时，诊断精度为58.4％，当截止值设定为8ng / ml时，诊断精度为58.4％。在术前术前血清CEA的患者中，血清CEA的血清CEA> = 8ng / ml的患者的复发存活率显着降低，而不是<8ng / ml的血清CEA的患者（p = 0.0018）。结论：通过根据术前血清CEA分别设定截止值，增强了复发性血清CEA的诊断准确性。 （c）2017年由S. Karger AG，巴塞尔发布的提交人

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