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首页> 外文期刊>Reproductive toxicology >Aspirin pre-treatment modulates ozone-induced fetal growth restriction and alterations in uterine blood flow in rats
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Aspirin pre-treatment modulates ozone-induced fetal growth restriction and alterations in uterine blood flow in rats

机译：阿司匹林预处理调节臭氧诱导的胎儿生长限制和大鼠子宫血流的改变

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摘要

Prenatal exposure to ozone has been linked to low birth weight in people and fetal growth restriction in rats. Clinical recommendations suggest use of low dose aspirin to lower risk of preeclampsia and intrauterine growth restriction in high-risk pregnancies, yet its utility in mitigating the postnatal effects of gestational ozone exposure is unknown. The present study investigated the possibility of low dose aspirin to mitigate the effects of ozone exposure during pregnancy. Exposure to ozone impaired uterine arterial flow and induced growth restriction in fetuses of both sexes. Aspirin treatment induced marginal improvements in ozone-induced uterine blood flow impairment. However, this resulted in a protection of fetal weight in dams given aspirin only in early pregnancy. Aspirin administration for the entirety of gestation increased placental weight and reduced antioxidant status, suggesting that prolonged exposure to low dose aspirin may induce placental inefficiency in our model of growth restriction.
机译：产前暴露于臭氧与大鼠人和胎儿生长限制的低出生体重相关联。临床建议表明，使用低剂量阿司匹林以降低预坦克敏和高风险妊娠的风险，但其在减轻妊娠臭氧暴露的后期影响的效用是未知的。本研究研究了低剂量阿司匹林的可能性，以减轻臭氧暴露在妊娠期间的影响。暴露于臭氧受损的子宫动脉流动和两性胎儿诱导的生长限制。阿司匹林治疗诱导臭氧诱导的子宫血流损伤的边际改善。然而，这导致仅在妊娠早期服用阿司匹林的坝中保护胎儿重量。阿司匹林给予全部妊娠期胎盘重量和降低的抗氧化剂状态，表明低剂量阿司匹林的延长暴露可能会诱导我们的生长限制模型中的胎盘效率低下。

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