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首页> 外文期刊>Obesity >Hepatic Steatosis is Common in Adolescents with Obesity and PCOS PCOS and Relates to De Novo De Novo Lipogenesis but not Insulin Resistance
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Hepatic Steatosis is Common in Adolescents with Obesity and PCOS PCOS and Relates to De Novo De Novo Lipogenesis but not Insulin Resistance

机译：肝脏脂肪变性在具有肥胖和PCOS PCOS的青少年中是常见的，并且涉及De Novo de Novo脂肪生成，但不是胰岛素抵抗

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Objective Increased liver fat and type 2 diabetes are prevalent in women with polycystic ovarian syndrome (PCOS) and cause excess mortality, yet little is known about their development during adolescence. The objective of this study was to measure hepatic steatosis and related metabolic contributors in girls with obesity, with and without PCOS. Methods Nondiabetic adolescents with obesity, 41 with PCOS (PCOS; age 15.0 [13.0‐16.0] years, BMI 35.2?±?0.61 kg/m 2 ) and 30 without PCOS (OB; age 14.5 [13.0‐17.0], BMI 33.2?±?1.8), were studied. Visceral and liver fat were assessed with MRI. Serum measures included androgens and 16:1 and 18:1 N7 fatty acids specific to de novo lipogenesis. Adipose, hepatic, and peripheral insulin sensitivity (IS) were assessed with a four‐phase hyperinsulinemic‐euglycemic clamp with isotope tracers. Results Forty‐nine percent of the PCOS group had hepatic steatosis versus fourteen percent of the OB group ( P = 0.02), and the PCOS group had higher N7 (43?±?4 vs. 29?±?5 nmol/g; P = 0.02). Peripheral IS was lower in PCOS (9.4 [7.2‐12.3] vs. 14.5 [13.1‐18.05 mg/lean kg/min]; P 0.001) as was hepatic ( P = 0.006) and adipose IS ( P = 0.005). Percent liver fat correlated with N7 ( R ?=?0.46, P = 0.02) and visceral fat ( R ?=?0.42, P 0.001), not androgens or peripheral IS. Conclusions Nearly 50% of nondiabetic girls with PCOS and obesity have hepatic steatosis, which relates to visceral fat and lipogenesis, but not to IS or androgens.
机译：目标增加的肝脏脂肪和2型糖尿病在具有多囊卵巢综合征（PCOS）的女性中普遍存在，并导致过量的死亡率，但在青春期期间的发育很少。本研究的目的是测量患有肥胖的女孩的肝脏脂肪变性和相关的代谢贡献，有没有PCOS。方法用肥胖，41种带PCOS（PCOS;年龄15.0 [13.0-16.0]岁，BMI 35.2？±0.61千克/ M 2）和30，没有PCOS（OB;年龄14.5 [13.0-17.0]，BMI 33.2，BMI 33.2，BMI 33.2，BMI 33.2，BMI 33.2，BMI 33.2，BMI 33.2，BMI 33.2，BMI 33.2，BMI 33.2，BMI 33.2，BMI 35.2）和30岁的肥胖青少年研究了±1.8）。用MRI评估内脏和肝脏脂肪。血清措施包括Androgens和16：1和18：1 N7脂肪酸，特异于Novo脂肪生成。用具有同位素示踪剂的四相高胰岛素 - 神经血糖夹具评估脂肪，肝和外周胰岛素敏感性（IS）。结果49％的PCOS组具有肝脏脂肪变性，而OB组的十四百分比（P = 0.02），PCOS组具有更高的N7（43？±4与29？±5 nmol / g; P. = 0.02）。外周在PCOS中较低（9.4 [7.2-12.3]与14.5 [13.1-18.05mg /瘦kg / min]; p <0.001），如肝（p = 0.006）和脂肪是（p = 0.005）。肝脂肪百分比与N7（r？= 0.46，p = 0.02）和内脏脂肪（r？= 0.42，p <0.001），而不是Antrogens或外周。结论近50％的PCOS和肥胖的非糖尿病女孩具有肝脏脂肪变性，其涉及内脏脂肪和脂肪生成，但不属于或雄激素。

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  • 来源
    《Obesity》 |2016年第11期|共8页
  • 作者

    Cree‐Green Melanie; Bergman Bryan C.; Coe Gregory V.; Newnes Lindsey; Baumgartner Amy D.; Bacon Samantha; Sherzinger Ann; Pyle Laura; Nadeau Kristen J.;

  • 作者单位

    Department of Pediatrics Division of Pediatric EndocrinologyUniversity of Colorado Anschutz;

    Department of Medicine Division of EndocrinologyUniversity of Colorado Anschutz Medical;

    Department of Pediatrics Division of Pediatric EndocrinologyUniversity of Colorado Anschutz;

    Department of Pediatrics Division of Pediatric EndocrinologyUniversity of Colorado Anschutz;

    Department of Pediatrics Division of Pediatric EndocrinologyUniversity of Colorado Anschutz;

    Department of Medicine Division of EndocrinologyUniversity of Colorado Anschutz Medical;

    Department of RadiologyUniversity of Colorado Anschutz Medical CampusAurora Colorado USA;

    Department of PediatricsUniversity of Colorado Anschutz Medical CampusAurora Colorado USA;

    Department of Pediatrics Division of Pediatric EndocrinologyUniversity of Colorado Anschutz;

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  • 正文语种 eng
  • 中图分类 内分泌腺疾病及代谢病;
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