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首页> 外文期刊>Oncology letters >Melatonin treatment induces apoptosis through regulating the nuclear factor-kappa B and mitogen-activated protein kinase signaling pathways in human gastric cancer SGC7901 cells
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Melatonin treatment induces apoptosis through regulating the nuclear factor-kappa B and mitogen-activated protein kinase signaling pathways in human gastric cancer SGC7901 cells

机译：褪黑激素治疗通过调节人胃癌SGC7901细胞中的核因子-Kappa B和丝裂原活化蛋白激酶信号通路诱导细胞凋亡

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摘要

Melatonin, which is synthesized by the pineal gland and released into the blood, exhibits antitumor properties. However, the mechanisms underlying these effects, particularly in stomach cancer, remain unknown. In the present study, the effect of melatonin on the nuclear factor (NF)-kappa B signaling pathway and the mitogen-activated protein kinase signaling pathway, involving p38 and c-Jun-N-terminal kinase (JNK), were investigated in SGC7901 gastric cancer cells. In addition, the effect of melatonin on the survival, migration and apoptosis of these cells was investigated in vitro in order to evaluate the use of melatonin for the treatment of gastric cancer. The results of the present study revealed that melatonin decreased the viability and migration of SGC7901 cells. Furthermore, melatonin induced apoptosis. Melatonin was identified to elevate the expression levels of phosphorylated (p)-p38 and p-JNK protein, and decrease the expression level of nucleic p-p65. These results suggest that the protein levels of p65, p38 and JNK are associated with the survival of SGC7901 cells following treatment with melatonin. The optimal concentration of melatonin was demonstrated to be 2 mM, which significantly induced apoptosis following a 24 h treatment period. These findings suggest that conflicting growth signals in cells may inhibit the efficacy of melatonin in the treatment of gastric cancer. Therefore, adjunct therapy would be required to improve the efficacy of melatonin in the treatment of cancer.
机译：由松果腺合成并释放到血液中的褪黑激素表现出抗肿瘤性质。然而，这些效果的机制，特别是在胃癌中，仍然是未知的。在SGC7901研究了在SGC7901中研究了褪黑素对核因子（NF）-Kappa信令途径和丝肠激活蛋白激酶信号传导途径和丝丝化活化的蛋白激酶信号通路（JNK）的影响。胃癌细胞。此外，在体外研究褪黑激素对这些细胞的存活，迁移和凋亡的影响，以评估褪黑素治疗胃癌的使用。本研究结果表明，褪黑素降低了SGC7901细胞的活力和迁移。此外，褪黑激素诱导细胞凋亡。鉴定褪黑激素以提高磷酸化（P）-P38和P-JNK蛋白的表达水平，并降低核状P-P65的表达水平。这些结果表明，P65，P38和JNK的蛋白质水平与用褪黑素处理后SGC7901细胞的存活相关。褪黑激素的最佳浓度证明是2mm，其在24小时治疗期后显着诱导细胞凋亡。这些发现表明细胞中的生长信号冲突可能抑制褪黑素在胃癌治疗中的疗效。因此，需要辅助治疗来改善褪黑素在癌症治疗中的疗效。

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  • 来源
    《Oncology letters》 |2017年第2期|共8页
  • 作者

    Li Weimin; Wang Zhonglue; Chen Yina; Wang Kaijing; Lu Ting; Ying Fei; Fan Mengdi; Li Zhiyin; Wu Jiansheng;

  • 作者单位

    Hangzhou Normal Univ Dept Gastroenterol Affiliated Hosp Hangzhou 310000 Zhejiang Peoples R;

    Hangzhou Normal Univ Dept Gastroenterol Affiliated Hosp Hangzhou 310000 Zhejiang Peoples R;

    Wenzhou Med Univ Affiliated Hosp 1 Dept Gastroenterol Bldg 1 South Baixiang St Wenzhou 325000;

    Wenzhou Med Univ Affiliated Hosp 1 Dept Gastroenterol Bldg 1 South Baixiang St Wenzhou 325000;

    Wenzhou Med Univ Affiliated Hosp 1 Dept Gastroenterol Bldg 1 South Baixiang St Wenzhou 325000;

    Wenzhou Med Univ Affiliated Hosp 1 Dept Gastroenterol Bldg 1 South Baixiang St Wenzhou 325000;

    Zhejiang Univ Dept Endocrinol Int Hosp Hangzhou 310000 Zhejiang Peoples R China;

    Hangzhou Normal Univ Dept Gastroenterol Affiliated Hosp Hangzhou 310000 Zhejiang Peoples R;

    Wenzhou Med Univ Affiliated Hosp 1 Dept Gastroenterol Bldg 1 South Baixiang St Wenzhou 325000;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 肿瘤学;
  • 关键词

    melatonin; nuclear factor-kappa B; p38; c-Jun-N-terminal kinase; viability; apoptosis;

    机译：褪黑素;核因子-Kappa B;p38;C-JUN-N-末端激酶;活力;凋亡;

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