...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Oncology Research >Knockdown of DDX46 Inhibits the Invasion and Tumorigenesis in Osteosarcoma Cells
【24h】

Knockdown of DDX46 Inhibits the Invasion and Tumorigenesis in Osteosarcoma Cells

机译：DDX46的敲低抑制骨肉瘤细胞中的入侵和肿瘤

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

DDX46, a member of the DEAD-box (DDX) helicase family, is involved in the development of several tumors. However, the exact role of DDX46 in osteosarcoma and the underlying mechanisms in tumorigenesis remain poorly understood. Thus, in the present study, we explored the role of DDX46 in osteosarcoma and the underlying mechanisms. Our results demonstrated that the expression levels of DDX46 in both mRNA and protein were greatly elevated in human osteosarcoma tissues and cell lines. Knockdown of DDX46 obviously inhibited osteosarcoma cell proliferation and tumor growth in vivo. In addition, knockdown of DDX46 also significantly suppressed migration and invasion in osteosarcoma cells. Furthermore, knockdown of DDX46 substantially downregulated the phosphorylation levels of PI3K and Akt in SaOS2 cells. In summary, the present results have revealed that DDX46 plays an important role in osteosarcoma growth and metastasis. Knockdown of DDX46 inhibited osteosarcoma cell proliferation, migration, and invasion in vitro and tumor growth in vivo. Therefore, DDX46 may be a potential therapeutic target for the treatment of osteosarcoma.
机译：DDX46是死箱（DDX）螺旋酶家族的成员，参与了几种肿瘤的发展。然而，DDX46在骨肉瘤中的确切作用以及肿瘤发生中的潜在机制仍然明白。因此，在本研究中，我们探讨了DDX46在骨肉瘤和潜在机制中的作用。我们的结果表明，人骨瘤组织和细胞系中mRNA和蛋白质中DDX46的表达水平大大升高。 DDX46的敲低明显抑制了体内骨肉瘤细胞增殖和肿瘤生长。此外，DDX46的敲低也显着抑制了骨肉瘤细胞中的迁移和侵袭。此外，DDX46的敲低基本上下调了SAOS2细胞中PI3K和AKT的磷酸化水平。总之，目前的结果表明，DDX46在骨肉瘤生长和转移中起重要作用。 DDX46的敲低抑制了体内体外骨肉瘤细胞增殖，迁移和侵袭。因此，DDX46可以是治疗骨肉瘤的潜在治疗靶标。

著录项

  • 来源
    《Oncology Research》 |2017年第3期|共9页
  • 作者

    Jiang Feng; Zhang Dengfeng; Li Guojun; Wang Xiao;

  • 作者单位

    Henan Univ Huaihe Hosp Dept Orthoped 8 Baobei Rd Kaifeng 475000 Henan Province Peoples R China;

    Henan Univ Huaihe Hosp Dept Orthoped 8 Baobei Rd Kaifeng 475000 Henan Province Peoples R China;

    Henan Univ Huaihe Hosp Dept Orthoped 8 Baobei Rd Kaifeng 475000 Henan Province Peoples R China;

    Henan Univ Huaihe Hosp Dept Orthoped 8 Baobei Rd Kaifeng 475000 Henan Province Peoples R China;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 肿瘤学;
  • 关键词

    DDX46; Osteosarcoma; Metastasis; PI3K/Akt pathway;

    机译：DDX46;骨肉瘤;转移;PI3K / AKT途径;

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号