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Evaluation of the role of ultrasound biomicroscopy in advanced retinoblastoma: A prospective study on Asian Indian children

机译：超声生物综合症在高级视网膜母细胞瘤中的作用评价：亚洲印度儿童的前瞻性研究

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Aim: To evaluate the role of ultrasound biomicroscopy (UBM) in retinoblastoma (RB). Methods: Children with advanced unilateral RB were included. UBM was performed to look for tumour invasion into the anterior segment (AS) and for evaluation of quantitative parameters. Enucleation was done and UBM findings were correlated with histopathology. The main outcome measures were sensitivity and specificity of UBM for detecting AS invasion and comparison of quantitative parameters between the tumour affected and fellow eyes. Results: Fifty patients were evaluated. The mean age was 2.76 +/- 1.63 years. Enucleation was performed in 50 eyes. The sensitivity and specificity of UBM for AS invasion were 80% (95% CI, 44-97%) and 95% (95% CI, 83-99%), respectively. UBM showed a sensitivity and specificity of 100% (95% CI, 59-100%) and 95% (95% CI, 84-99%), respectively, for iris invasion, 88% (95% CI, 47-100%) and 100% (95% CI, 92-100%), respectively, for ciliary body invasion, and 63% (95% CI, 24-91%) and 100% (95% CI, 92-100%), respectively, for anterior chamber (AC) angle invasion. Quantitative parameters were studied in 100 eyes. As compared to the fellow eyes, the AC angle was narrow (p < 0.05), posterior chamber was shallow (p = 0.004) and zonular length was increased (p = 0.001) in RB eyes. Conclusion: This clinicopathological study provides valuable insights into the role of UBM for evaluation of anterior extension of RB and for assessment of architectural changes in the AS due to the tumour.
机译：目的：评估超声生物显微镜（UBM）在视网膜母细胞瘤（RB）中的作用。方法：包括高级单方面RB的儿童。进行UBM以寻找肿瘤侵入到前段（AS）并进行定量参数的评估。完成enucleation，UBM发现与组织病理学相关。主要结果测量是uBM的敏感性和特异性，用于检测肿瘤之间的侵袭和肿瘤之间的定量参数的比较。结果：评估五十名患者。平均年龄为2.76 +/- 1.63岁。 enucleation在50只眼中进行。 UBM作为侵袭的敏感性和特异性分别为80％（95％CI，44-97％）和95％（95％CI，83-99％）。 UBM显示出100％（95％CI，59-100％）和95％（95％CI，84-99％）的敏感性和特异性，用于虹膜侵袭，88％（95％CI，47-100％ ）分别为100％（95％CI，92-100％），分别用于睫状体侵袭，分别为63％（95％CI，24-91％）和100％（95％CI，92-100％） ，前房（AC）角侵入。在100只眼睛中研究了定量参数。与同伴眼睛相比，AC角度窄（P <0.05），后腔室浅（P = 0.004），rb眼中增加（p = 0.001）。结论：该临床病理学研究为UBM对RB前延伸评估的作用提供了有价值的见解，并用于评估肿瘤的建筑变化的建筑变化。

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