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Impact of oral potentially malignant disorder subtypes on all‐cause and cause‐specific mortality in males

机译：口腔潜在恶性疾病的影响亚型对男性的所有原因和造成特异性死亡率

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Abstract Objectives To quantify the effect of oral potentially malignant disorder (OPMD) subtypes on mortality from oral cancer and type 2 diabetes among areca nut chewers and/or cigarette smokers. Materials and Methods A retrospective cohort design was devised to follow 14,749 men attending community‐based screening program for oral cancer between 1998 and 2000 and followed until 2010. The Cox proportional hazards regression model was applied to assess the effect of OPMD on death. Results A total of 1,291(8.75%) patients were detected as OPMD. Among those free of T2DM at baseline, the elevated risk for death from T2DM was noted for OSF (aHR?=?3.62, 95% CI: 1.25–10.51) and erythroplakia (aHR?=?5.01, 95% CI: 1.17–21.45). The elevated risk for all‐cause death for OPMD was mainly explained by deaths from oral cancer and T2DM but not other causes of death. Conclusions Oral potentially malignant disorder, particularly OSF and erythroplakia, in male cigarette smokers and/or areca nut chewers led to an incremental elevated risk of T2DM mortality in the way of being distal to the occurrence of T2DM, implying that early detection and prevention of OPMD may not only reduce oral cancer mortality but also result in the reduction of T2DM mortality.
机译：摘要目的是量化口腔潜在恶性疾病（OPMD）亚型对口腔癌死亡率和2型糖尿病在槟榔咀嚼物和/或香烟吸烟者中的影响。材料和方法设计了一种回顾性队列设计，遵循1998年至2000年间的基于社区的口腔癌症筛查计划的14,749名男性，并持续到2010年。将Cox比例危害回归模型用于评估OPMD对死亡的影响。结果总共1,291名（8.75％）患者被检测为OPMD。在基线中没有T2DM的那些中，OSF（AHR？= 3.62,95％CI：1.25-10.51）和erythloplakia（AHR？= 5.01,95％CI：1.17-21.45 ）。 OPMD的全因死亡风险升高主要由口腔癌和T2DM的死亡来解释，但不是其他死亡原因。结论雄性卷烟吸烟者和/或ARECA坚果咀嚼物中的口腔潜在恶性疾病，特别是OSF和赤藓杆菌，导致T2DM的发生方式增加了T2DM死亡率的升高风险，这意味着早期检测和预防OPMD不仅可以减少口服癌死亡率，而且导致T2DM死亡率的降低。

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