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首页> 外文期刊>Osteoarthritis and cartilage >Assessment of rat articular cartilage maturation using 50-MHz quantitative ultrasonography.
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Assessment of rat articular cartilage maturation using 50-MHz quantitative ultrasonography.

机译：使用50-MHz定量超声检查评估大鼠关节软骨成熟。

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OBJECTIVE: The objective was to assess the relationship between maturation-related structural changes of articular cartilage and variations of acoustic parameters estimated using high frequency ultrasonography. DESIGN: Patellae taken from 48 immature Wistar male rats and divided into six age groups (from five to 11 weeks old) were explored in vitro using 50-MHz scanning acoustic microscopy, then assessed by histology for the analysis of the cartilage cell distribution and fibrillar collagen organization. The variation of cartilage proteoglycan and collagen content with age was evaluated. Thickness measurements performed on both B-scan images and histologic sections were compared. Ultrasonic radiofrequency signals reflected by the cartilage surface and backscattered from its internal matrix were processed to estimate the integrated reflection coefficient (IRC) and apparent integrated backscatter (AIB). RESULTS: One-way ANOVA indicated that acoustic parameters and thickness change significantly (P < 0.05) as the animal matures because of age-related changes in cartilage composition and morphology. A moderate correlation was found between IRC and the animal age. The parameter decreased slightly but significantly over time. However, a good correlation was observed between the rat age and the AIB, which decreased significantly over time. The parameter variation was mostly related to the changes in collagen fiber orientation, and/or to a change in cell size, density and organization. CONCLUSIONS: Current results indicate that acoustic properties of cartilage are affected by maturation-related cartilage changes. This suggests that high frequency ultrasonography may serve as a useful means for the investigation of cartilage matrix structural changes occurring under various clinical circumstances, like those observed during osteoarthritis, and for the evaluation of the efficacy of specific therapeutics. Copyright 2001
机译：目的：目的是评估与高频超声检查估计的关节软骨相关结构变化与声学参数变化之间的关系。设计：从48个未成熟的Wistar雄性大鼠中取出的髌骨，并在体外使用50MHz扫描声学显微镜进行六个年龄组（从五到11周龄），然后通过组织学评估用于分析软骨细胞分布和Fibrillar的分析胶原蛋白组织。评估软骨蛋白多糖和胶原蛋白含量的变异。比较了对B扫描图像和组织学部分进行的厚度测量。由软骨表面反射并由其内部矩阵反向散射的超声波射频信号被处理以估计集成的反射系数（IRC）和表观集成的反向散射（AIB）。结果：单向ANOVA表明声学参数和厚度显着变化（P <0.05），因为由于软骨组成和形态的年龄相关变化，动物成熟。在IRC和动物年龄之间发现了中等的相关性。该参数随着时间的推移略有而显着降低。然而，在大鼠年龄和AIB之间观察到良好的相关性，随着时间的推移而显着降低。参数变异大多数与胶原纤维取向的变化和/或细胞大小，密度和组织的变化有关。结论：目前的结果表明，软骨的声学性质受相关的软骨变化的影响。这表明高频超声检查可以作为调查在各种临床环境下发生的软骨基质结构变化的有用手段，如在骨关节炎期间观察到的那些，以及评估特定治疗剂的疗效。版权所有2001.

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