Multiscale and multimodal structure-function analysis of intervertebral disc degeneration in a rabbit model

Ashinsky B. G.; Gullbrand S. E.; Bonnevie E. D.; Mandalapu S. A.; Wang C.; Elliott D. M.; Han L.; Mauck R. L.; Smith H. E.

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Multiscale and multimodal structure-function analysis of intervertebral disc degeneration in a rabbit model

机译：兔模型中椎间盘变性的多尺度和多峰结构函数分析

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摘要

Objectives: The objective of this study was to perform a quantitative analysis of the structural and functional alterations in the intervertebral disc during in vivo degeneration, using emerging tools that enable rigorous assessment from the microscale to the macroscale, as well as to correlate these outcomes with noninvasive, clinically relevant imaging parameters.

机译：目的：本研究的目的是使用新兴工具在体内变性中进行椎间盘中结构和功能改变的定量分析，这些工具可以使微米对Macroscale进行严格评估，以及与这些结果相关联非侵入性，临床相关的成像参数。

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来源
《Osteoarthritis and cartilage》 |2019年第12期|共10页
作者
Ashinsky B. G.; Gullbrand S. E.; Bonnevie E. D.; Mandalapu S. A.; Wang C.; Elliott D. M.; Han L.; Mauck R. L.; Smith H. E.;
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作者单位

Univ Penn Dept Orthopaed Surg McKay Orthopaed Res Lab Philadelphia PA 19104 USA;

Univ Penn Dept Orthopaed Surg McKay Orthopaed Res Lab Philadelphia PA 19104 USA;

Univ Penn Dept Orthopaed Surg McKay Orthopaed Res Lab Philadelphia PA 19104 USA;

Univ Penn Dept Orthopaed Surg McKay Orthopaed Res Lab Philadelphia PA 19104 USA;

Drexel Univ Sch Biomed Engn Sci &

Hlth Syst Philadelphia PA 19104 USA;

Univ Delaware Dept Biomed Engn Newark DE USA;

Drexel Univ Sch Biomed Engn Sci &

Hlth Syst Philadelphia PA 19104 USA;

Univ Penn Dept Orthopaed Surg McKay Orthopaed Res Lab Philadelphia PA 19104 USA;

Univ Penn Dept Orthopaed Surg McKay Orthopaed Res Lab Philadelphia PA 19104 USA;

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原文格式 PDF
正文语种 eng
中图分类骨科学（运动系疾病、矫形外科学）;
关键词
Intervertebral disc degeneration; Animal model; Magnetic resonance imaging; Atomic force microscopy;

机译：椎间盘退化;动物模型;磁共振成像;原子力显微镜;

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专利

1. Multiscale and multimodal structure-function analysis of intervertebral disc degeneration in a rabbit model [J] . Ashinsky B. G., Gullbrand S. E., Bonnevie E. D., Osteoarthritis and cartilage . 2019,第12期

机译：兔模型中椎间盘变性的多尺度和多峰结构函数分析
2. A novel magnetic resonance imaging postprocessing technique for the assessment of intervertebral disc degeneration—Correlation with histological grading in a rabbit disc degeneration model [J] . Kyle Sheldrick, Uphar Chamoli, Koichi Masuda, JOR spine. . 2019,第3期

机译：评估椎间盘退变的新型磁共振成像后处理技术-与兔椎间盘退变模型中组织学分级的相关性
3. Mechanism of intervertebral disc degeneration caused by nicotine in rabbits to explicate intervertebral disc disorders caused by smoking. [J] . Iwahashi M, Matsuzaki H, Tokuhashi Y, Spine . 2002,第13期

机译：尼古丁引起的兔椎间盘退变机制加剧了吸烟引起的椎间盘疾病。
4. INTERVERTEBRAL DISC SHAPE VARIATION AND ITS RELATIONSHIP TO DEGENERATION USING PRINCIPAL COMPONENTS ANALYSIS OF A POPULATION OF MR IMAGES [C] . John M. Peloquin, Jonathon H. Yoder, Nathan T. Jacobs, ASME summer bioengineering conference;SBC2012 . 2012

机译：MR图像人群的主成分分析椎间盘形状变化及其与退化的关系
5. Multiscale and Multimodal Structure-Function Analysis of Intervertebral Disc Degeneration and Regeneration [D] . Ashinsky, Beth Gayle. 2020

机译：椎间盘退化和再生的多尺度和多模式结构函数分析
6. A novel magnetic resonance imaging postprocessing technique for the assessment of intervertebral disc degeneration—Correlation with histological grading in a rabbit disc degeneration model [O] . Kyle Sheldrick, Uphar Chamoli, Koichi Masuda, 2019

机译：评估椎间盘退变的新型磁共振成像后处理技术-与兔椎间盘退变模型中组织学分级的相关性
7. Evaluation of Lumbar Intervertebral Disc Degeneration Using T1ρ and T2 Magnetic Resonance Imaging in a Rabbit Disc Injury Model [O] . Tetsuhiro Ishikawa, Atsuya Watanabe, Hiroto Kamoda, 2018

机译：兔盘损伤模型中T1ρ和T2磁共振成像评价腰椎间盘变性

Multiscale and multimodal structure-function analysis of intervertebral disc degeneration in a rabbit model

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