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首页> 外文期刊>ORL: Journal for oto-rhino-laryngology and its borderlands >Combined Growth Factor and Gene Therapy: An Approach for Hair Cell Regeneration and Hearing Recovery
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Combined Growth Factor and Gene Therapy: An Approach for Hair Cell Regeneration and Hearing Recovery

机译：综合生长因子和基因治疗：一种毛细胞再生和听力恢复的方法

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Introduction: Fibroblast growth factor, nerve growth factor neurotrophins, and insulin-like growth factor 1 are considered 3 families of growth factors that can be involved in the process of otic neurogenesis. In this respect, otic neurons can also be connected with mechanoreceptors in the ear, the hair cells (HCs), as well as the central nervous system. As a growth factor is combined with gene transfer technology, it can be used for hair cell regeneration. Gene therapy can be similarly employed to introduce genes into a system in order to induce the expression of genes for therapeutic agents, to replace defective genes, or to re-program supporting or surrounding cells to acquire the phenotype of lost or damaged cells in order to repair or regenerate the damaged tissue. Objective: The purpose of this review article was to investigate the epigenetic and growth factors involved in the differentiation pathway of embryonic stem cells (ESCs) into HCs and auditory neurons (ANs). Methods: To this end, the databases of Directory of Open Access Journals, Google Scholar, PubMed (NLM), LISTA (EBSCO), as well as Web of Science were searched. Results: Given the results available in the related literature, the differentiation efficacy of ESCs toward the ANs and the HCs, the important role of growth factors, and 3 different strategies of application of miRNA, epigenetic regulation, and preparation of three-dimensional (3D) environments were suggested to be taken into consideration in order to improve these studies in the future. Furthermore, the role of epige-netic mechanisms and miRNA in this differentiation process became quite obvious; hence, the utilization of such procedures in the near future would be significant. Conclusion: Combining several techniques with a synergic effect (such as growth factor gene therapy and 3D environments) seemed to lead to obtaining the best results as a therapeutic strategy. (c) 2018 S. Karger AG, Basel
机译：介绍：成纤维细胞生长因子，神经生长因子神经营养素和胰岛素样生长因子1被认为是3个生长因子的系列，可参与肠球神经发生过程。在这方面，耳状神经元也可以与耳朵中的机械感，头发细胞（HCS）以及中枢神经系统连接。随着生长因子与基因转移技术结合，可用于毛细胞再生。基因治疗可以类似地用于将基因引入系统中以诱导治疗剂的基因的表达，以取代缺陷的基因，或重新编程支撑或周围细胞以获取丢失或受损细胞的表型以获取丢失或受损细胞的表型修复或再生受损的组织。目的：本综述文章的目的是探讨胚胎干细胞（ESC）分化为HCS和听觉神经元（ANS）的脑膜遗传和生长因素。方法：为此，搜索了开放访问期刊目录，谷歌学者，PubMed（NLM），Lista（EBSCO）以及科学网站以及科学网站的数据库。结果：鉴于相关文献中的结果，ESC对ANS和HCS的分化疗效，生长因子的重要作用以及3种不同的MiRNA，表观遗传调控和三维施工策略（3D ）建议考虑环境，以便在未来改善这些研究。此外，对尖端 - 核算机制和miRNA在这种分化过程中的作用变得非常明显;因此，在不久的将来利用此类程序将是显着的。结论：将若干技术与协同效应（如生长因子基因治疗和3D环境相结合，似乎导致获得最佳结果作为治疗策略。 （c）2018年S. Karger AG，巴塞尔

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