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首页> 外文期刊>Modern rheumatology >Anticentromere antibody-positive primary Sjogren's syndrome: Epitope analysis of a subset of anticentromere antibody-positive patients
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Anticentromere antibody-positive primary Sjogren's syndrome: Epitope analysis of a subset of anticentromere antibody-positive patients

机译:抗肾细胞抗体阳性Sjogren的综合征:抗体抗体阳性患者的熵分析

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摘要

Objectives: Anticentromere antibody (ACA) is generally considered to be a serological marker for systemic sclerosis (SSc). ACA-positive patients with primary Sjogren's syndrome (pSS) have also been reported. ACA often recognizes centromere proteins (CENPs): CENP-A, CENP-B, and CENP-C, and sometimes reacts to heterochromatin protein 1 (HP1)alpha. We compared the reactivity against six different epitopes for three ACA-positive clinical subgroups: 29 patients with pSS, 36 SSc patients with sicca symptoms, and 28 SSc patients without sicca symptoms.
机译:目的:抗肾细胞抗体(ACA)通常被认为是全身硬化(SSC)的血清学标志物。 据报道,亚卡阳性患有原发性Sjogren综合征(PSS)的患者。 ACA经常识别Centromere蛋白质(CENP):CENP-A,CENP-B和CENP-C,有时对异铬胺蛋白1(HP1)α反应。 我们将反应性与三种不同临床亚组的六种不同表位进行比较:29例PSS,36例SSC患者SICCA症状,28例SSC患者没有SICCA症状。

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