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首页> 外文期刊>Stem cells international >Bone Marrow-Derived Mesenchymal Stem Cells Repair Necrotic Pancreatic Tissue and Promote Angiogenesis by Secreting Cellular Growth Factors Involved in the SDF-1 alpha/CXCR4 Axis in Rats
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Bone Marrow-Derived Mesenchymal Stem Cells Repair Necrotic Pancreatic Tissue and Promote Angiogenesis by Secreting Cellular Growth Factors Involved in the SDF-1 alpha/CXCR4 Axis in Rats

机译：骨髓衍生的间充质干细胞修复坏死的胰腺组织，并通过分泌大鼠SDF-1α/ CXCR4轴的细胞生长因子来促进血管生成

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摘要

Acute pancreatitis (AP), a common acute abdominal disease, 10%-20% of which can evolve into severe acute pancreatitis (SAP), is of significant morbidity and mortality. Bone marrow-derived mesenchymal stem cells (BMSCs) have been reported to have a potential therapeutic role on SAP, but the specific mechanism is unclear. Therefore, we conducted this experiment to shed light on the probable mechanism. We validated that SDF-1 alpha significantly stimulated the expressions of VEGF, ANG-1, HGF, TGF-beta, and CXCR4 in BMSCs, which were inhibited by its receptor agonist, AMD3100. The capacities of proliferation, migration, and repair of human umbilical vein endothelial cells were enhanced by BMSCs supernatant. Meanwhile, BMSCs supernatant could also promote angiogenesis, especially after the stimulation with SDF-1 alpha. In vivo, the migration of BMSCs was regulated by SDF-1 alpha/CXCR4 axis. Moreover, transplanted BMSCs could significantly alleviate SAP, reduce the systematic inflammation (TNF-alpha down arrow, IL-1 beta down arrow, IL-6 down arrow, IL-4 up arrow, IL-10 up arrow, and TGF-beta up arrow), and promote tissue repair and angiogenesis (VEGF up arrow, ANG-1 up arrow, HGF up arrow, TGF-beta up arrow, and CD31 up arrow), compared with the SAP and anti-CXCR4 groups. Taken together, the results showed that BMSCs ameliorated SAP and the SDF-1 alpha/CXCR4 axis was involved in the repair and regeneration process.
机译：急性胰腺炎（AP），常见的急性腹部疾病，10％-20％可以发展成严重的急性胰腺炎（SAP），具有显着的发病率和死亡率。据报道，骨髓衍生的间充质干细胞（BMSCs）在SAP上具有潜在的治疗作用，但具体机制尚不清楚。因此，我们在可能的机制上进行了这种实验。我们验证了SDF-1α显着刺激了BMSCs中VEGF，Ang-1，HGF，TGF-Beta和CXCR4的表达，其受其受体激动剂抑制的AMD3100。通过BMSCS上清液增强了人脐静脉内皮细胞的增殖，迁移和修复的能力。同时，BMSCS上清液还可以促进血管生成，尤其是用SDF-1α刺激后。在体内，BMSCs的迁移由SDF-1α/ CXCR4轴调节。此外，移植的BMSCs可以显着缓解SAP，减少系统炎症（TNF-Alpha向下箭头，IL-1 Beta向下箭头，IL-6向下箭头，IL-4向上箭头，IL-10向上箭头和TGF-Beta箭头）和促进组织修复和血管生成（VEGF向上箭头，ang-1向上箭头，HGF向上箭头，TGF-Beta向上箭头和CD31向上箭头），与SAP和抗CXCR4组相比。结果，结果表明，BMSCS改善SAP和SDF-1α/ CXCR4轴涉及修复和再生过程。

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  • 来源
    《Stem cells international》 |2015年第1期|共20页
  • 作者

    Qian Daohai; Gong Jian; He Zhigang; Hua Jie; Lin Shengping; Xu Chenglei; Meng Hongbo; Song Zhenshun;

  • 作者单位

    Tongji Univ Med Shanghai Peoples Hosp 10 Dept Gen Surg Shanghai 200072 Peoples R China;

    Tongji Univ Med Shanghai Peoples Hosp 10 Dept Gen Surg Shanghai 200072 Peoples R China;

    Tongji Univ Med Shanghai Peoples Hosp 10 Dept Gen Surg Shanghai 200072 Peoples R China;

    Tongji Univ Med Shanghai Peoples Hosp 10 Dept Gen Surg Shanghai 200072 Peoples R China;

    Tongji Univ Med Shanghai Peoples Hosp 10 Dept Gen Surg Shanghai 200072 Peoples R China;

    Tongji Univ Med Shanghai Peoples Hosp 10 Dept Gen Surg Shanghai 200072 Peoples R China;

    Tongji Univ Med Shanghai Peoples Hosp 10 Dept Gen Surg Shanghai 200072 Peoples R China;

    Tongji Univ Med Shanghai Peoples Hosp 10 Dept Gen Surg Shanghai 200072 Peoples R China;

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  • 正文语种 eng
  • 中图分类 生物工程学（生物技术）;
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