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Acute Leukemias of Ambiguous Lineage Clarification on Lineage Specificity

机译:急性白血病模糊谱系澄清谱系特异性

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Acute leukemias of ambiguous lineage (ALAL) include acute undifferentiated leukemia and mixed-phenotype acute leukemia (MPAL). This article provides an overview of the diagnosis of ALAL and focuses on the data accounting for the current lineage-assignment criteria for blasts harboring more than one lineage-associated marker. In addition, the currently known molecular data are reviewed, which show that MPAL-associ-ated gene mutations, methylation signatures, and expression profiles are a mixture of those seen in both acute myeloid leukemia and acute lympho-blastic leukemia. Finally, the prognosis and current treatments of MPAL are briefly discussed.
机译:模糊血统(Alal)的急性白血病包括急性未分化的白血病和混合表型急性白血病(MPAL)。 本文概述了ALAL的诊断,并专注于对斑点的当前血统分配标准的数据核算,这些标准涉及多个谱系相关标记的爆炸。 此外,综述了当前已知的分子数据,表明MPAL-ASSEASIES基因突变,甲基化签名和表达谱是在急性髓性白血病和急性淋巴粉体白血病中观察到的那些的混合物。 最后,简要讨论了对MPAL的预后和目前治疗。

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