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Haematological alterations in non-human hosts infected with Trypanosoma cruzi: a systematic review

机译：感染锥虫瘤克鲁齐的非人体宿主的血液学改变：系统审查

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摘要

American trypanosomiasis is a neglected tropical disease whose spectrum has not been quite understood, including the impact of Trypanosoma cruzi infection on the haematological parameters of different vertebrate hosts. Thus, this study was designed to compare the pattern of haematological changes induced by T. cruzi infection in order to identify possible species-specific differences among taxons. We also aimed at evaluating the use of this parameter as a tool for diagnosis during the acute phase, when symptoms are usually masked. For this purpose, we performed a systematic search on PubMed and Scopus databases to retrieve original studies published until August 2016. Thirty-one studies were selected using Prisma strategy, which were then submitted to data extraction and methodological bias analysis. Half of the studies showed that the number of erythrogram decreased in infected animals, indicating anaemia. In 68.2% of the studies, the total amount of leukogram values increased, suggesting infection. The main methodological limitations were insufficient information for T. cruzi strains identification, inoculation routes and parasitological characterization. Most of the mammalian species analysed showed the same pattern of haematological changes following T. cruzi infection, indicating that haematological parameters might direct the diagnosis of Chagas disease in the initial phase.
机译：美国锥虫病是一种被忽视的热带病，其谱目尚未得到很明确，包括锥虫瘤Cruzi感染对不同脊椎动物宿主的血液学参数的影响。因此，该研究旨在比较T.Cruzi感染诱导的血液学变化的模式，以确定分类的可能种类特异性差异。我们还旨在评估该参数作为急性期间诊断工具的使用，当通常屏蔽症状时。为此目的，我们对PubMed和Scopus数据库进行了系统搜索，以检索出版的原始研究，直到2016年8月。使用Prisma策略选择了三十一项研究，然后提交数据提取和方法偏见分析。一半的研究表明，感染动物的红细胞图数减少，表明贫血。在68.2％的研究中，白细值的总量增加，表明感染。主要的方法局限性是T.Cruzi菌株的信息不足，接种途径和寄生学表征。分析的大多数哺乳动物物种表明，在克鲁齐感染后，表明血液学参数可能会引导初始阶段诊断Chagas病的诊断。

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