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首页> 外文期刊>Parasitology >Evaluation of salinomycin isolated from Streptomyces albus JSY-2 against the ciliate, Ichthyophthirius multifiliis
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Evaluation of salinomycin isolated from Streptomyces albus JSY-2 against the ciliate, Ichthyophthirius multifiliis

机译：对综合症，ICHThyophthirius Multifiliis的Streptomyces Albus Jsy-2分离的蝾螈分离的评估

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摘要

The present study was undertaken to investigate the antiparasitic activity of extracellular products of Streptomyces albus. Bioactivity-guided isolation of chloroform extracts affording a compound showing potent activity. The structure of the compound was elucidated as salinomycin (SAL) by EI-MS, 1H NMR and 13C NMR. In vitro test showed that SAL has potent anti-parasitic efficacy against theronts of Ichthyophthirius multifiliis with 10 min, 1, 2, 3 and 4 h (effective concentration) EC50 (95% confidence intervals) of 2.12 (2.22–2.02), 1.93 (1.98–1.88), 1.42 (1.47–1.37), 1.35 (1.41–1.31) and 1.11 (1.21–1.01) mg L?1. In vitro antiparasitic assays revealed that SAL could be 100% effective against I. multifiliis encysted tomonts at a concentration of 8.0 mg L?1. In vivo test demonstrated that the number of I. multifiliis trophonts on Erythroculter ilishaeformis treated with SAL was markedly lower than that of control group at 10 days after exposed to theronts (P < 0.05). In the control group, 80% mortality was observed owing to heavy I. multifiliis infection at 10 days. On the other hand, only 30.0% mortality was recorded in the group treated with 8.0 mg L?1 SAL. The median lethal dose (LD50) of SAL for E. ilishaeformis was 32.9 mg L?1.
机译：本研究探讨了Streptomyces Albus细胞外产物的抗披啶活性。生物活动引导的氯仿提取物的​​分离，其具有显示有效活性的化合物。通过EI-MS，1H NMR和13C NMR阐明化合物的结构作为盐霉素（SAL）。体外测试表明，SAL对ICHThyophthirius Multifiliis的有效的抗寄生功效，10分钟，1,2,3和4小时（有效浓度）EC50（95％置信区间）为2.12（2.22-2.02），1.93（ 1.98-1.88），1.42（1.47-1.37），1.35（1.41-1.31）和1.11（1.21-1.01）mg l？1。体外抗披物测定结果显示，SAL可以是100％的对I.浓度为8.0mg的浓度为8.0mgα1的umerfiliis。体内测试证明，在暴露于视网膜后10天，用SAL处理的红细胞Ilishaeformis上的I.多亿型颅内无晶体的数量明显低于对照组（P <0.05）。在对照组中，由于重的I.重量，据观察了80％的死亡率。10天。另一方面，含有8.0mg的含量溶液的组仅记录30.0％的死亡率。 E.ILishaeformis的Sal的中值致命剂量（LD50）为32.9mgL≥1。

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