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首页> 外文期刊>Parasitology >Paragonimus and paragonimiasis in West and Central Africa: unresolved questions
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Paragonimus and paragonimiasis in West and Central Africa: unresolved questions

机译：非洲西部和中部的锥虫和锥虫病：未解决的问题

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摘要

Paragonimiasis, human lung fluke disease, is a foodborne anthropozoonosis caused by the trematodes assigned to Paragonimus and is regarded by the World Health Organization as a Neglected Tropical Disease (NTD). The life cycle of this medically important parasite centres on a complex freshwater biological community that includes two intermediate hosts: a mollusc and a decapod, usually a brachyuran. Although there is a perception that the biology, symptoms, diagnosis and treatment of Paragonimus is well understood, in reality, this is not the case, especially in Africa. Much remains unknown concerning the life-cycle of the parasite, its transmission, the current epidemiology of the disease, diagnosis and the effectiveness of treatment. Furthermore, cases of paragonimiasis may be misdiagnosed as resistant tuberculosis (TB) because of the similar pulmonary symptoms and no remission after anti TB therapy. The endemic foci of human paragonimiasis in Africa have been reported mainly in the forest zones of Upper Guinea (Liberia, Guinea and Ivory Coast) and Lower Guinea (Nigeria, Cameroon, Equatorial Guinea and Gabon). Despite the perceived medical importance of paragonimiasis, relatively little attention has been paid to this NTD since its discovery in Africa in the 1960s. This review focuses on the current understanding of the life cycle and transmission of Paragonimus in Africa, discusses its diagnosis and public health importance and highlights many outstanding gaps in the knowledge that still exist for this NTD.
机译：副血症是人肺氟克病，是由分配给锥虫的震颤引起的食源性乌托，被世界卫生组织视为被忽视的热带病（NTD）。这种医学上重要的寄生虫中心的生命周期在复杂的淡水生物群落中，包括两个中间宿主：MOLLUSC和凹凸，通常是BRACHYURAN。虽然具有普拉戈宫的生物学，症状，诊断和治疗的看法，但实际上，这不是这种情况，特别是在非洲。关于寄生虫的生命周期，其传播，目前疾病流行病学，诊断和治疗的有效性的遗骸尚不清楚。此外，由于肺症状和抗TB治疗后没有缓解，锥虫病的病例可能被误诊为抗性结核病（TB）。据报道，非洲人锥虫病的特有焦点主要是在几内亚（利比里亚，几内亚和象牙海岸）和低几内亚（尼日利亚，喀麦隆，赤道几内亚和加蓬）的森林区。尽管对锥虫病的感知至关重要，但自20世纪60年代在非洲发现以来，这一NTD已经支付了相对较少的关注。本综述侧重于目前对非洲帕拉戈斯的生命周期和传播的了解，讨论了其诊断和公共卫生的重要性，并突出了这个NTD仍然存在的知识中的许多未突出的差距。

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