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首页> 外文期刊>Particle & Particle Systems Characterization: Measurement and Description of Particle Properties and Behavior in Powders and Other Disperse Systems >Combinational Chemotherapy and Photothermal Therapy Using a Gold Nanorod Platform for Cancer Treatment
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Combinational Chemotherapy and Photothermal Therapy Using a Gold Nanorod Platform for Cancer Treatment

机译：使用金纳米德平台进行癌症治疗的组合化疗和光热疗

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Multimodal approaches combined with various nanomaterials and advanced techniques have been developed for synergistic cancer treatment. Among various therapies, conventional chemotherapy (CHT) is a direct cancer treatment that can produce unintended side effects due to nonspecific action on both the tumor and normal cells; patient-friendly photothermal therapy (PTT) may be able to treat embedded tumors in vital regions with minimal invasion but does not guarantee complete removal of cancers. However, the combination of CHT-PTT may provide a promising tool for direct cancer treatment with minimal side effects. In this regard, nanostructured materials, such as gold nanorods with tuned size and surface characteristics, are key components designed to enhance the heating capacity and active or passive delivery of drugs to the tumor site. In this review, the pioneering work synergizing CHT and PTT is summarized, and the current state-of-the-art in the development of inorganic and organic nanocomposites for combinational therapy is described.
机译：已经开发了与各种纳米材料和先进技术相结合的多式联运方法用于协同癌症治疗。在各种疗法中，常规化疗（CHT）是一种直接癌症治疗，其由于肿瘤和正常细胞的非特异性作用而产生意外的副作用;患者友好的光热疗疗法（PTT）可以能够在重要地区治疗嵌入的肿瘤，侵袭最小，但不能保证完全去除癌症。然而，CHT-PTT的组合可以提供具有最小副作用的直接癌症治疗的有希望的工具。在这方面，纳米结构材料，例如具有调谐尺寸和表面特性的金纳米棒，是旨在增强对肿瘤部位的加热容量和激活或被动递送药物的关键部件。在本文中，概述了CHT和PTT的开创性工作协同作用，并且描述了当前在开发用于组合治疗的无机和有机纳米复合材料中的最新技术。

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