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首页> 外文期刊>Pediatric nephrology: journal of the International Pediatric Nephrology Association >Proteinuria and progression of pediatric chronic kidney disease: lessons from recent clinical studies
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Proteinuria and progression of pediatric chronic kidney disease: lessons from recent clinical studies

机译：蛋白尿和小儿慢性肾病的进展：近期临床研究的课程

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Proteinuria in children with chronic kidney disease (CKD) is common and its etiology differs from that in adults. How proteinuria influences the rate of progression of CKD has been analyzed in multiple retrospective clinical studies and more recently in a few prospective ones. In this review I summarize the results, strengths and weaknesses of each of these studies. The findings of several retrospective studies in children with CKD have confirmed what we have learned from adult studies on the association between proteinuria and worsening kidney function. Larger prospective clinical studies have examined the effects of proteinuria on the rate of decline of kidney function and the risk of end-stage kidney disease. They have also considered children with glomerular and, more importantly, the more common, congenital causes of CKD. Current studies have important strengths but also a few weaknesses that limit the validity of the conclusions which can be drawn. There is still a need for large clinical trials that focus primarily on studying the influence of proteinuria on kidney function and on finding remedies that delay progression.
机译：患有慢性肾病（CKD）的儿童蛋白尿是常见的，其病因与成年人的病因不同。多次回顾性临床研究中，蛋白尿如何影响CKD的进展速度，最近在一些前瞻性临床研究中进行了分析。在这篇综述中，我总结了这些研究中的每项研究的结果，优势和缺点。 CKD儿童的几项回顾性研究的调查结果证实了我们从成人研究中了解到的蛋白尿和肾功能恶化之间的关系。更大的前瞻性临床研究检测了蛋白尿对肾功能下降率的影响和终级肾病的风险。他们还认为肾小球的孩子，更重要的是，CKD的先天性原因更为常见。目前的研究具有重要的优势，但也有一些弱点限制了可以绘制的结论的有效性。仍然需要大的临床试验，主要集中在研究蛋白尿对肾功能的影响以及发现延迟进展的补救措施。

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