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Celastrol as a pentacyclic triterpenoid with chemopreventive properties

机译：Celastrol作为五类近亲三萜，化学预防性质

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摘要

Celastrol is a highly investigated anticancer moiety. It is a pentacyclic triterpenoid, isolated several decades ago with promising role in chemoprevention. Celastrol has been found to target multiple proinflamma-tory, angiogenic and metastatic proteins. Inhibition of these targets results in significant reduction of cancer growth, survival and metastasis. This review summarizes the varied molecular targets of celastrol along with insight into the various recently published clinical, preclinical and industrial patents (2011-2017). From thousands of years, natural products have been widely used for health and disease treatment. Several natural products, including celastrol, have shown significant pharmacological importance, and have been processed and developed as potential pharmacological agents with effective antioxidative, anti-inflammatory, antiangiogenic and anticarcinogenic properties. Celastrol is a pentacyclic triterpenoid, belonging to the family of quinone methides. Several in vitro and in vivo animal studies with celastrol have shown that it exhibits antioxidant, anti-inflammatory, anticancer and insecticidal activities. Celastrol has also been shown to have exorbitant corpulence regulating effects in mice. For some times, celastrol has been used for the treatment of autoimmune diseases, asthma, chronic inflammation and neurodegenerative disorders.
机译：Celastrol是一种高度调查的抗癌部分。这是一个五十年前孤立的五环三萜，在化学预防方面具有有希望的作用。已发现Celastrol针对多个幼儿生成和转移蛋白质。抑制这些靶标导致癌症生长，存活和转移的显着降低。本综述总结了Celastrol的各种分子目标以及深入了解最近公布的临床，临床前和工业专利（2011-2017）。从数千年来看，天然产品已被广泛用于健康和疾病治疗。包括Celastrol（包括Celastrol），包括Celastrol的几种天然产品，并已被加工和开发为具有有效抗氧化，抗炎，抗血管生成和抗毒性的潜在药理剂。 Celastrol是一个五环三萜类化合物，属于醌类化合物。几种体外和体内动物研究表明它表现出抗氧化剂，抗炎，抗癌和杀虫活性。 Celastrol也已被证明在小鼠中具有过高的腐败效果。有时，Celastrol已被用于治疗自身免疫疾病，哮喘，慢性炎症和神经变性障碍。

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