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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >DID it or DIDn't it? Exploration of a failure to replicate binge-like alcohol-drinking in C57BL/6J mice
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DID it or DIDn't it? Exploration of a failure to replicate binge-like alcohol-drinking in C57BL/6J mice

机译：是不是或不是吗？ 探索在C57BL / 6J小鼠中重复狂欢饮酒

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We previously reported that commercially-sourced C57BL/6J (B6) male mice with a history of adult-onset binge drinking exhibit anxiety-like behavior in early withdrawal, while the negative affective state incubates during protracted withdrawal in adolescent-onset binge-drinking males. As the results of such studies are potentially confounded by age-related differences in reactivity to environmental stress, we employed a 2-bottle-choice DID procedure (20 and 40% alcohol; 20 min habituation to the drinking cage) to examine the effects of binge drinking on negative affect in male and female, adult and adolescent, B6 mice from our university colony. Unexpectedly, the mice in the initial experiment exhibited very low alcohol intake, with little sign of withdrawal-induced negative affect. This failure to replicate prompted us to examine how the duration of drinking cage habituation, the number of alcohol concentrations presented and the animal source might influence the propensity to binge-drink. Herein, we show that both male and female adult mice from our colony will binge drink when allowed 45 min to habituate to the drinking cages, irrespective of whether mice are offered a choice between 2, 3 or 4 alcohol concentrations. Further, when drinking under 4-bottle-choice procedures (5, 10, 20 and 40% alcohol), adult-onset binge-drinking females exhibit robust negative affect in early withdrawal akin to that reported previously for adult males; however, the negative affective state persists for at least 30 days into withdrawal. Also unlike males, adolescent-onset binge-drinking females exhibit some signs of negative affect, as well as potentiated alcohol intake, in early withdrawal, which persist into later withdrawal. These latter data suggest that the age-related differences in the temporal patterning of the negative affective state produced by alcohol withdrawal may vary as a function of sex, which may have implications for understanding sex differences in the etiology of affective disorders and alcoholism co-morbidity.
机译：我们之前报道的是，在早期戒断中，具有成人发作狂犬病患者的历史表现出类似焦虑的行为的商业源性C57BL / 6J（B6）雄性小鼠，而负性情感状态在青少年 - 发作的饮用男性的持续的戒断期间孵育。由于这些研究的结果可能会被与环境压力的反应性的年龄相关差异混淆，我们使用了一个2瓶选择的程序（20％和40％的酒精; 20分钟习惯于饮用笼）来检查来自大学殖民地的男性和女性，成人和青少年的B6小鼠的阴性影响对消极影响的狂欢饮用。出乎意料地，初始实验中的小鼠表现出非常低的酒精摄入量，戒断引起的负面影响几乎没有迹象。这种未能恢复促使我们检查饮用笼养习惯的持续时间，呈现的酒精浓度数量和动物来源可能会影响狂犬病饮料的倾向。在此，我们表明，当允许45分钟时，来自我们的菌落的雄性和女性成年小鼠将习惯饮用笼时饱和，而无论小鼠是否提供2,3或4醇浓度之间的选择。此外，在饮用4瓶选择程序（5,10,20和40％酒精）时，成人发作的泪水饮用女性在早期戒断前表现出强大的负面影响，类似于以前为成年男性报告的情况;然而，负面情感状态仍然存在至少30天的撤回。同样与男性不同，青少年 - 发作狂犬病饮用的女性表现出一些负面影响的迹象，以及早期退出时的有效的酒精摄入量，持续后撤退。这些后者数据表明，酒精戒断产生的负面情感状态的时间图案中的临时模式的差异可能因性行为而有所不同，这可能对理解情感疾病和酗酒的病因差异的性差异有影响。

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