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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Increased anxiety-related behavior in male and female adult rats following early and late adolescent exposure to 3,4-methylenedioxymethamphetamine (MDMA)
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Increased anxiety-related behavior in male and female adult rats following early and late adolescent exposure to 3,4-methylenedioxymethamphetamine (MDMA)

机译：在早期和晚期青少年暴露于3,4-甲基二氧基戊酰胺（MDMA）后患有母女性成年大鼠的焦虑相关行为

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Subsequent behavioral effects in adulthood of daily exposure to MDMA during early or late adolescence were assessed in both male and female rats. From either postnatal day (PND) 35 (early adolescence) or PND45 (late adolescence), PVG/c rats of each sex were exposed via intraperitoneal injections to saline or 10 mg/kg MDMA for 10 consecutive days. They were regularly weighed during treatment and again on PND90. At this age, their anxiety-related behavior was determined from frequencies of ambulation, rearing, grooming, defecation and occupancy of the center and corners of an open field, as well as entries into and time spent in the light compartment of a light-dark box. Spatial and working memories were assessed by preferences for a novel Y-maze arm, and by recognition of a novel object. MDMA-exposed rats gained less weight during treatment than saline controls but were heavier on PND90 depending on their sex or age when treated. As shown by decreased open-field ambulation (for males only) and increased defecation plus fewer entries into the light compartment of the light-dark box and entries into both arms of a Y maze, MDMA exposure increased adult anxiety-related behavior particularly for rats treated during late adolescence. There was no evidence of any effects on either spatial or working memory. ? 2012 Elsevier Inc.
机译：在雄性和雌性大鼠中评估了在早期或晚期青春期日期前或晚期青春期过去的日常暴露于MDMA的后续行为效应。从后期（PND）35（早期青春期）或PND45（晚期青春期），每种性别的PVG / C大鼠通过腹腔注射到盐水或10mg / kg MDMA连续10天。它们在治疗期间经常称重，并在PND90中再次受到称重。在这个时代，他们的焦虑相关行为是从开放领域的中心和角落的常规，饲养，修饰，排便和占据的频率和占据的频率以及在浅色舱室里花费的参赛作品盒子。通过对新型Y型迷宫臂的偏好来评估空间和工作记忆，并通过识别新的对象。 MDMA暴露的大鼠在治疗过程中的重量较少，而不是盐水对照，但根据治疗时的性别或年龄在PND90上较重。如下面的开放式公平（仅适用于男性）和更高的排便加上较轻暗箱的光隔室的排序和较少的条目，并将MDMA暴露增加了尤其是对大鼠的成人焦虑相关行为增加在晚期青春期治疗。没有关于空间或工作记忆的任何影响。还2012年elsevier公司

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