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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Late aging alters behavioral sensitivity to ethanol in a sex-specific manner in Fischer 344 rats
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Late aging alters behavioral sensitivity to ethanol in a sex-specific manner in Fischer 344 rats

机译：晚期老化在Fischer 344大鼠中以性别特异性的方式改变对乙醇的行为敏感性

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Responsiveness to ethanol (EtOH) differs as a function of age. Adolescent rodents are less sensitive than adults to the sedative effects of EtOH, whereas they show enhanced sensitivity to EtOH-induced social facilitation. Late aging is associated with a natural decline in social behavior and aging-related peculiarities in sensitivity to EtOH have been largely unexplored. Whether there are sex differences in the behavioral response to EtOH during late aging remains unknown. Thus, behavioral responses to EtOH in male and female Fischer (F) 344 rats aged 4–5?months (adult) and 19–20?months (aging) were examined. First, the effects of saline and EtOH (0.5 and 0.75?g/kg) on social interaction were assessed. Social investigation and contact behavior were lower in aging animals and higher in females. Interestingly, in aged females, social contact behavior was increased following a 0.5?g/kg EtOH dose, whereas the same dose suppressed social contact in aged males. Behavioral sensitivity to the sedative effects of 3.0 and 3.5?g/kg EtOH was assessed with the loss of righting reflex (LORR) test. Although latency to LORR did not differ as a function of age or sex, aged rats showed significantly greater LORR duration and significantly lower blood ethanol concentrations (BECs) at regaining of the righting reflex relative to adults. In addition, females had a lower LORR duration, regardless of age; no sex differences were evident in BECs at awakening. In a second experiment, blood ethanol concentrations (BECs) over time were assessed following 0.75, 1.5, and 3.0?g/kg EtOH in 3-, 12-, and 18-month-old male and female F344 rats. Aged rats had higher peak BECs following 3.0?g/kg EtOH, whereas few age or sex differences were apparent at lower doses. Taken together, these data indicate that late aging is associated with altered sensitivity to the social facilitating effects and sedative effects of EtOH.
机译：对乙醇（EtOH）的反应性与年龄的函数不同。青少年啮齿动物对EtOH的镇静作用敏感，而它们表明对Etoh引起的社会促进的增强敏感性。晚期衰老与社会行为的自然下降有关，并且对EtOH的敏感性有关的特殊性在很大程度上是未开发的。在晚期老化期间是否存在对EtOH的行为反应的性别差异仍然未知。因此，对4-5岁的男性和雌性费 - 氏菌（F）344大鼠的行为应对4-5岁的大鼠（成人）和19-20个月（老化）进行了检查。首先，评估盐水和EtOH（0.5和0.75μm≤g/ kg）对社交相互作用的影响。社会调查和接触行为较低，衰老和女性较高。有趣的是，在年迈的女性中，0.5克/ kg eTOH剂量后的社会接触行为增加，而同样的剂量抑制了男性年龄的社会接触。通过损失抗反射（Lorr）试验来评估对3.0和3.5〜5〜5〜5〜5℃的镇静效应的行为敏感性。虽然Lorr潜伏期与年龄或性别的功能没有不同，但老鼠患者均显示出明显更大的洛氏持续时间和显着降低血液乙醇浓度（BECS）相对于成人恢复抗反射。此外，雌性较低的LORS持续时间，无论年龄大小;在唤醒时，没有性差异是明显的。在第二次实验中，在3-，12-和18个月的男性F344大鼠中，评估血液乙醇浓度（BECS）随时间的随时间进行评估。老年大鼠在3.0？g / kg eTOH后具有较高的峰值，而少剂量较少或性别差异是显而易见的。总之，这些数据表明，晚期老化与对EtOH的社会促进效果和镇静作用的敏感性改变。

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