• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Philosophical Transactions of the Royal Society of London, Series B. Biological Sciences >Adaptive mechanisms driving maladaptive pain: how chronic ongoing activity in primary nociceptors can enhance evolutionary fitness after severe injury
【24h】

Adaptive mechanisms driving maladaptive pain: how chronic ongoing activity in primary nociceptors can enhance evolutionary fitness after severe injury

机译：促进适应机制促使患者疼痛：慢性伤害者的持续活动如何在严重损伤后提高进化的健身

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Chronic pain is considered maladaptive by clinicians because it provides no apparent protective or recuperative benefits. Similarly, evolutionary speculations have assumed that chronic pain represents maladaptive or evolutionarily neutral dysregulation of acute pain mechanisms. By contrast, the present hypothesis proposes that chronic pain can be driven by mechanisms that evolved to reduce increased vulnerability to attack from predators and aggressive conspecifics, which often target prey showing physical impairment after severe injury. Ongoing pain and anxiety persisting long after severe injury continue to enhance vigilance and behavioural caution, decreasing the heightened vulnerability to attack that results from motor impairment and disfigurement, thereby increasing survival and reproduction (fitness). This hypothesis is supported by evidence of animals surviving and reproducing after traumatic amputations, and by complex specializations that enable primary nociceptors to detect local and systemic signs of injury and inflammation, and to maintain low-frequency discharge that can promote ongoing pain indefinitely. Ongoing activity in nociceptors involves intricate electro-physiological and anatomical specializations, including inducible alterations in the expression of ion channels and receptors that produce persistent hyperexcitability and hypersensitivity to chemical signals of injury. Clinically maladaptive chronic pain may sometimes result from the recruitment of this powerful evolutionary adaptation to severe bodily injury.
机译：临床医生认为慢性疼痛是因为它没有提供明显的保护或恢复效益。类似地，进化簇已经假设慢性疼痛代表急性疼痛机制的不适性或进化中性的中性失调。相比之下，目前的假设提出了慢性疼痛可以通过演变，以减少捕食者和侵略性的攻击攻击攻击增加的机制，这通常是捕获在严重伤害后显示物理障碍的猎物。严重伤害持续持续持续持续痛苦，继续加强警惕性和行为谨慎，降低了攻击的脆弱性，从而造成的攻击，从而提高生存和繁殖（健身）。这种假设支持动物患者饲存和繁殖后的创伤截肢，并通过复杂的专业化，使原发性伤害者能够检测局部和全身损伤的迹象，并保持低频放电，可以无限期地促进持续的疼痛。 Nociceptors中的持续活性涉及复杂的电生理和解剖学专业，包括在离子通道和受体表达中产生持续低渗性和对损伤的化学信号的过敏的受体中的诱导变化。临床患者慢性疼痛有时可能因招募这种强大的进化适应而导致严重的身体伤害。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号