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首页> 外文期刊>Philosophical Transactions of the Royal Society of London, Series B. Biological Sciences >Immune gene regulation in the gut during metamorphosis in a holo- versus a hemimetabolous insect
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Immune gene regulation in the gut during metamorphosis in a holo- versus a hemimetabolous insect

机译：Holo-versual昆虫在变态过程中肠道的免疫基因调节

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摘要

During metamorphosis, holometabolous insects completely replace the larval gut and must control the microbiota to avoid septicaemia. Rapid induction of bactericidal activity in the insect gut at the onset of pupation has been described in numerous orders of the Holometabola and is best-studied in the Lepidoptera where it is under control of the 20-hydroxyecdysone (20E) moulting pathway. Here, using RNAseq, we compare the expression of immune effector genes in the gut during metamorphosis in a holometabolous (Galleria mellonella) and a hemimetabolous insect (Gryllus bimaculatus). We find that in G. mellonella, the expression of numerous immune effectors and the transcription factor GmEts are upregulated, with peak expression of three antimicrobial peptides (AMPs) and a lysozyme coinciding with delamination of the larval gut. By contrast, no such upregulation was detectable in the hemimetabolous Gr. himaculatus. These findings support the idea that the upregulation of immune effectors at the onset of complete metamorphosis is an adaptive response, which controls the microbiota during gut replacement.
机译：在变态期间，储藏昆虫完全取代幼虫肠道，必须控制微生物群以避免败血症。在许多井草上描述了在蛹开始处的昆虫肠道中昆虫肠道中的杀菌活性的快速诱导，并且在鳞片中最佳地研究，其中含有20-羟基粥样酮（20E）蜕皮途径。这里，使用RNASEQ，我们将免疫效应基因在肠道（Galleria Mellonella）和半虫昆虫（Gryllus Bimaculatus）中的变态期间的肠道中的免疫效应基因的表达。我们发现，在G. mellonella，许多免疫效应器的表达和转录因子导血剂的表达是上调的，具有三种抗微生物肽（AMP）的峰值表达和与幼虫肠道的分层重合的溶菌酶。相反，在半啮合GR中没有检测到这种上述。 Himaculatus。这些发现支持了完全变态发作在完全变态的发作的免疫效应器的上调是一种适应性反应，可在肠道替换过程中控制微生物群。

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