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Fiber-reinforced composite hydrogels for bioadhesive and sealant applications

机译：用于生物粘附和密封剂应用的纤维增强复合水凝胶

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The use of bioadhesives and sealants for wound closure and healing applications is becoming more and more popular, particularly when other techniques, such as stapling or suturing, are impractical or inefficient. Loading adhesives with fibers has tremendous potential for improving their mechanical properties. The concept of fiber-reinforced bioadhesives and sealants is novel and has not been investigated to date. In the present study, natural cellulose fibers were selected for enhancement of bioadhesive properties. A bioadhesive formulation based on a combination of gelatin and alginate crosslinked with water-soluble carbodiimide was used as a generic formulation for this study, on the basis of our previous studies. The polymeric matrix and the cellulose fibers showed high affinity, which resulted in a dramatic increase in the viscosity and in the burst strength. They moderately affected the curing time, swelling, and weight loss. A mixed response was found in the compression modulus and the bonding strength in lap shear. We demonstrated that fiber-reinforced bioadhesives have a great potential for surgical sealant applications because of improvement in the cohesive strength of the composite hydrogel. This study presents proof of the concept of using fibers for the enhancement of bioadhesive properties as a result of fiber-reinforcement and may comprise the basis for future studies in this field. Copyright (C) 2017 John Wiley & Sons, Ltd.
机译：用于伤口闭合和愈合应用的生物粘合剂和密封剂正在变得越来越受欢迎，特别是当其他技术（例如装订或缝合）是不切实际或效率的。用纤维装载粘合剂具有改善其机械性能的巨大潜力。纤维增强的生物粘附和密封剂的概念是新颖的，尚未调查到目前为止。在本研究中，选择天然纤维素纤维以增强生物粘附性质。基于明胶和藻酸盐与水溶性碳二亚胺的结合的生物粘附制剂被用作本研究的通用配方，在我们之前的研究的基础上。聚合物基质和纤维素纤维显示出高亲和力，从而导致粘度和爆发强度的显着增加。它们适度影响固化时间，肿胀和减肥。在压缩模量和膝盖剪切中的粘合强度中发现了混合响应。我们证明，由于复合水凝胶的内聚强度改善，纤维增强的生物粘合剂具有巨大的手术密封剂应用的潜力。本研究提出了使用纤维的概念证明，纤维增强的增强生物粘附性能，并且可以包括该领域未来研究的基础。版权所有（c）2017 John Wiley＆Sons，Ltd。

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