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首页> 外文期刊>Plasmid: An International Journal Devoted to Extrachromosomal Gene Systems >Conjugative plasmids enable the maintenance of low cost non-transmissible plasmids
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Conjugative plasmids enable the maintenance of low cost non-transmissible plasmids

机译：共轭质粒能够维持低成本的非传式质粒

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摘要

Some plasmids can be transferred by conjugation to other bacterial hosts. But almost half of the plasmids are non-transmissible. These plasmid types can only be transmitted to the daughter cells of their host after bacterial fission. Previous studies suggest that non-transmissible plasmids become extinct in the absence of selection of their encoded traits, as plasmid-free bacteria are more competitive. Here, we aim to identify mechanisms that enable non-transmissible plasmids to persist, even if they are not beneficial. For this purpose, an individual based model for plasmid population dynamics was set up and carefully tested for structural consistency and plausibility. Our results demonstrate that non-transmissible plasmids can be stably maintained in a population, even if they impose a substantial burden on their host cells growth. A prerequisite is the co-occurrence of an incompatible and costly conjugative plasmid type, which indirectly facilitates the preservation of the non transmissible type. We suggest that this constellation might be considered as a potential mechanism maintaining plasmids and associated antibiotic resistances. It should be investigated in upcoming laboratory experiments.
机译：一些质粒可以通过与其他细菌宿主的缀合来转移。但是几乎一半的质粒是不可传播的。这些质粒类型只能在细菌裂变后传递给其宿主的子细胞。之前的研究表明，在没有选择它们的编码性状的情况下，非传染性质粒灭绝，因为不含质粒细菌更具竞争力。在这里，我们的目标是识别使得能够持续的非传染性质粒能持的机制，即使它们不利。为此目的，建立并仔细测试了基于质粒群体动力学的模型，以进行结构一致性和合理性。我们的结果表明，即使它们对其宿主细胞的生长施加了大量负担，也表明不传染性质粒可以稳定地保持在群体中。先决条件是一种不相容且昂贵的共轭质粒型的共同发生，其间接促进保存非传式型。我们认为该星座可能被认为是保持质粒和相关抗生素抗性的潜在机制。应该在即将到来的实验室实验中调查。

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