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首页> 外文期刊>Prevention science: the official journal of the Society for Prevention Research >Childhood Trauma and Two Stages of Alcohol Use in African American and European American Women: Findings from a Female Twin Sample
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Childhood Trauma and Two Stages of Alcohol Use in African American and European American Women: Findings from a Female Twin Sample

机译：童年创伤与非洲裔美国和欧洲妇女的两种阶段：女性双胞胎样本的调查结果

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摘要

The current investigation assessed for moderating effects of childhood trauma on genetic and environmental contributions to timing of alcohol use initiation and alcohol use disorder in African American (AA) and European American (EA) women. Data were drawn from diagnostic telephone interviews conducted with 3786 participants (14.6% AA) in a longitudinal female twin study. Childhood trauma was defined alternately as child maltreatment and more broadly to include other events (e.g., witnessing violence). Phenotypic associations between childhood trauma and alcohol outcomes were estimated using logistic regression analyses. Twin modeling was conducted to test for moderating effects of childhood trauma on the contributions of genetic and environmental factors to timing of initiation and alcohol use disorder. Under both definitions, childhood trauma was associated with early initiation (relative risk ratios: 1.90, 1.72) and alcohol use disorder (odds ratios: 1.92, 1.76). Yet gene by environment effects were observed only for child maltreatment and timing of initiation in EA women, with heritable influences less prominent in those who had experienced child maltreatment (0.35, 95% CI: 0.05–0.66 vs. 0.52, 95% CI: 0.30–0.73). We found more similarities than differences in the association of childhood trauma with alcohol outcomes across racial/ethnic groups, trauma type, and stages of alcohol use. However, findings suggest that the relative contribution of genetic factors to alcohol outcomes differs by childhood maltreatment history in EA women specifically in the earliest stage of alcohol use.
机译：目前调查评估儿童创伤对遗传和环境贡献的调节效果对非洲裔美国（AA）和欧洲（AA）和欧洲美国（EA）妇女的饮酒和酒精使用障碍的遗传和环境贡献。在纵向女性双床研究中，从3786名参与者（14.6％AA）进行的诊断电话访谈中汲取数据。儿童创伤是作为儿童虐待的交替定义，更广泛地包括其他事件（例如，目睹暴力）。使用Logistic回归分析估计儿童创伤和酒精结果之间的表型缔合。进行双床模型以测试儿童创伤对遗传和环境因素对起始和酒精使用障碍时机的贡献的调节效果。在这两种定义下，儿童创伤与早期开始（相对风险比率：1.90,1.72）和酒精使用障碍（差距：1.92,1.76）相关。然而，仅针对儿童虐待和在EA女性的发芽时间来观察到环境影响的基因，在经历过儿童虐待的人中的遗传影响较小（0.35,95％CI：0.05-0.66对0.52,95％CI：0.30 -0.73）。我们发现更多的相似之处比儿童创伤与种族/族裔群体，创伤类型和酒精使用阶段的饮酒结果的差异。然而，调查结果表明，遗传因素对酒精结果的相对贡献与EA女性的儿童虐待史如早到酒精使用的最早阶段。

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