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The significance of serum hepcidin on iron status in overweight and obese patients with iron-deficiency anemia

机译：血型肝素对缺铁性贫血患者超重和肥胖患者铁能的重要性

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BACKGROUND: Deficiency of iron is one of the most prevalent nutritional disorders, and obesity is an increasing nutritional problem, but only a few studies mention a possible association between them in Iraq. Adipocytes secrete adipokines, some of them are related to the inflammatory response in addition to hepcidin, a hormone that mediates iron metabolism. OBJECTIVES: This study aimed to assess the significance of serum hepcidin in obese patients with iron deficiency. PATIENTS MATERIALS AND METHODS: Ninty patients were separated into Group 1 (normal weight), Group 2 (30 overweight), and the Group 3 (30 obese). All patients were investigated by complete blood count, serum hepcidin, iron, total iron-binding capacity, and ferritin using the standard laboratory techniques. RESULTS: There were no significant differences among the groups regarding the severity of anemia, red cell indices, white blood cells, and platelets count. The obese group had significantly higher serum hepcidin and ferritin (P = 0.003, 0.040, respectively), while serum iron is lower. Serum hepcidin positively correlated with the serum ferritin but inversely correlated with serum iron. Increased hepcidin level in obesity could be related to inflammatory adipokines that effect on hepatic hepcidin transcription and hepcidin mRNA expression, in addition to the nonhepatic production of hepcidin in an autocrine manner; hepcidin, in turn, is responsible for low serum iron, but a high ferritin level in correlation to high hepcidin may explain by low-grade chronic inflammation associated with obesity. CONCLUSIONS: The severity of iron-deficiency anemia is not affected by body weight; however, significantly higher serum hepcidin and ferritin in the obese patient with a lower serum iron should be considered during the assessment of iron status in those patients.
机译：背景：铁的缺乏是最普遍的营养障碍之一，肥胖是营养问题的增加，但只有一些研究在伊拉克之间提出了可能的关联。脂肪细胞分泌adipokines，除了肝素外，其中一些与肝蛋白外的炎症反应有关，该激素介导铁代谢。目的：本研究旨在评估血型素在肥胖缺铁患者血清肝素的重要性。患者的材料和方法：第九款患者分为第1组（正常重量），第2组（30个超重），第3组（30肥胖）。使用标准实验室技术通过完全血计数，血清肝素，铁，总铁合容和铁蛋白来研究所有患者。结果：对贫血，红细胞指数，白细胞和血小板计数的严重程度的组无显着差异。肥胖组血清肝素和铁蛋白（P = 0.003,0.040）显着高，血清铁较低。血清Hepcidin与血清铁蛋白呈正相关，但与血清铁相反。肥胖症中的肝素水平增加可能与炎症性脂质对肝肝素转录和肝素mRNA表达的影响有关，除了以自分泌方式的肝素的非肝素产生;反过来，肝素负责低血清铁，但与高肝素相关的高铁蛋白水平可以通过与肥胖相关的低级慢性炎症来解释。结论：缺铁性贫血的严重程度不受体重的影响;然而，在评估那些患者的铁状况期间，应考虑肥胖血清患者的肥胖患者的血清肝素和铁蛋白。

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