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Corticostriatal-limbic correlates of sub-clinical obsessive-compulsive traits

机译：皮质血管肢体 - 肢体临床强迫性状相关性

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Obsessive-compulsive (OC) traits such as intrusive worrisome ideas or excessive concerns for threats are frequent in general population (5%-13%). However, the structural neural correlates of the sub-clinical OC traits remain largely unknown. Based on the data of obsessive-compulsive disorder (OCD), we hypothesized that the subcortical and cortical structures, constituting the cortico-striatal-thalamo-cortical circuit (CSTC) and the limbic system, could be associated with OC traits. Here we conducted voxel-based morphometry (VBM) in order to investigate fine grained volume changes of these structures in 49 non-clinical subjects. Analysis of structural covariances of these structures was also conducted. We identified volume changes associated with OC traits in the left putamen and the left amygdala. The results of structural covariance analysis revealed increased covariances in relation to the heightened OC traits between the left putamen to bilateral medial prefrontal cortex and to the left cerebellum, and between the left globus pallidus to the bilateral anterior cingulate cortices. The present finding of volume changes of the corticostriatal-limbic structures may reflect neuroplasticity associated with OC traits. Since the abnormality of these structures were also observed in the clinical OCD, the subclinical subjects with OC traits shared "neuronal obsessive traits" that might precondition OCD at the network level.
机译：强迫性（OC）特征如侵入性担忧的思想或对威胁的过度担忧经常在一般人群中（5％-13％）。然而，亚临床oC特征的结构神经相关性在很大程度上是未知的。基于强迫症（OCD）的数据，我们假设构成皮质脊髓型 - 皮质 - 皮质电路（CSTC）和肢体系统的皮质和皮质结构可以与OC特征相关。在这里，我们进行了基于体形态（VBM）（VBM），以便在49个非临床受试者中调查这些结构的细粒体积变化。还进行了这些结构的结构考究分析。我们鉴定了左侧垫片和左杏仁杆的oc特征相关的体积变化。结构协方差分析的结果揭示了与双侧内侧前额叶皮层和左脑叶片和左侧细胞之间的加强oc特征有关的共聚体，以及左侧球茎与双侧前刺铰霉菌菌之间的左侧。目前发现皮质棘环 - 肢体结构的体积变化可以反映与oC特征相关的神经塑性。由于在临床调查中也观察到这些结构的异常，因此具有oC特征的亚临床受试者共享“神经元强迫性特征”，这些受试者在网络水平处的前提是强调的“神经元强迫性特征”。

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