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首页> 外文期刊>Psychiatry Research. Neuroimaging >Posttraumatic stress disorder, social anxiety disorder and childhood trauma: Differences in hippocampal subfield volume
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Posttraumatic stress disorder, social anxiety disorder and childhood trauma: Differences in hippocampal subfield volume

机译：宫外应激障碍，社交焦虑障碍和儿童创伤：海马子场体积的差异

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Volume-based hippocampal findings in Social Anxiety Disorder (SAD) and Posttraumatic Stress Disorder (PTSD) have been inconsistent, with very little investigation of hippocampal subfields. We assessed the effects of early childhood trauma on hippocampal subfields in participants with SAD with and without early childhood trauma and PTSD, compared to healthy controls. The sample comprised 26 participants SAD with early childhood trauma, 22 participants with SAD without early childhood trauma, 17 with PTSD secondary to early childhood trauma and 25 control participants. We used Freesurfer version 6 to determine hippocampal subfield volumes. Findings included significant reduction in right parasubiculum volume between the PTSD group secondary to early childhood trauma and the SAD group without early childhood trauma, as well as a significant reduction in left HATA (Hippocampal Amygdala Transition Area) volume between PTSD with early childhood trauma compared to controls, as well as compared to SAD with early childhood trauma. These findings did withstand correction for multiple resting using the false discovery rate. Our findings of an association of reduced volumes in the parasubiculum and HATA regions with PTSD secondary to childhood trauma are interesting. Further work should investigate whether parasubiculum and HATA regional volume reductions in PTSD are a specific effect of early childhood trauma or a specific manifestation of PTSD pathology. Further work should also be undertaken to determine if hippocampal subfield atrophy is associated with SAD in the setting of early childhood maltreatment.
机译：社交焦虑症（悲伤）和宫外应激障碍（PTSD）的基于体积的海马结果一直不一致，对海马子场的研究非常少。与健康对照相比，我们评估了悲伤和没有早期儿童创伤和应激障碍的参与者的海马子场对海马子场的影响。该样本包含26名与会者，早期的幼儿创伤，22名与会伤心的参与者，没有早期儿童创伤，17名患有早期儿童创伤和25名控制参与者的PTSD。我们使用FreeSurfer版本6来确定海马子场卷。结果包括在没有早期儿童创伤的早期儿童创伤和悲伤组之间的PTSD组与伤心组之间的右寄生虫体积显着降低，以及与对照，以及与悲伤与早期儿童创伤相比。这些发现确实抵抗了使用假发现率多次休息的校正。我们对寄生和患有PTSD的寄生虫和HATA区域中减少的体积结合的调查结果是有趣的。进一步的工作应调查PTSD的寄生管和哈达区域体积减少是否是早期儿童创伤的特异性效果或应激病病理学的特异性表现。还应该进行进一步的工作，以确定海马子场萎缩是否与悲伤在幼儿虐待的环境中有关。

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