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Neuroimaging investigations of dorsal stream processing and effects of stimulus synchrony in schizophrenia

机译：精神分裂症刺激同步刺激同步刺激性的神经影像研究

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摘要

Impairments in auditory and visual processing are common in schizophrenia (SP). In the unisensory realm visual deficits are primarily noted for the dorsal visual stream. In addition, insensitivity to timing offsets between stimuli are widely reported for SP. The aim of the present study was to test at the physiological level differences in dorsal/ventral stream visual processing and timing sensitivity between SP and healthy controls (HC) using MEG and a simple auditory/visual task utilizing a variety of multisensory conditions. The paradigm included all combinations of synchronous/asynchronous and central/peripheral stimuli, yielding 4 task conditions. Both HC and SP groups showed activation in parietal areas (dorsal visual stream) during all multisensory conditions, with parietal areas showing decreased activation for SP relative to HC, and a significantly delayed peak of activation for SP in intraparietal sulcus (IPS). We also observed a differential effect of stimulus synchrony on HC and SP parietal response. Furthermore, a (negative) correlation was found between SP positive symptoms and activity in IPS. Taken together, our results provide evidence of impairment of the dorsal visual stream in SP during a multisensory task, along with an altered response to timing offsets between presented multisensory stimuli.
机译：在精神分裂症（SP）中，听觉和视觉处理中的损伤是常见的。在Unisurisory领域中，视觉缺陷主要针对背部视觉流引起的。此外，SP广泛报道了对刺激之间的定时偏移的不敏感性。本研究的目的是在SP和健康控制（HC）之间的背/腹流视觉处理和时序敏感度的目的差异，使用MEG和利用各种多思考条件的简单听觉/视觉任务。范例包括同步/异步和中央/外围刺激的所有组合，产生4个任务条件。 HC和SP组在所有多师病症中显示出在顶部区域（背部视觉流）中的激活，并且具有相对于HC的SP活化的垂直区域，以及在片内沟（IPS）中的显着延迟的活化峰值。我们还观察到刺激同步对HC和SP Paretal反应的差异效果。此外，在IPS中的SP阳性症状和活性之间发现了（阴性）相关性。我们的结果在一起提供了在多人症任务中在SP中损伤了背部视觉流的证据，以及对所呈现的多思索刺激之间的定时抵消的改变响应。

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