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Structural and functional alterations of the suicidal brain: An updated review of neuroimaging studies

机译:自杀脑的结构和功能改变:神经影像学研究的更新综述

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Brain imaging is a non-invasive and in vivo direct estimation of detailed brain structure, regional brain functioning and estimation of molecular processes in the brain. The main objective of this review was to analyze functional and structural neuroimaging studies of individuals at risk for suicide. We reviewed articles published between 2005 and 2018, indexed in PubMed and Medline, assessing structural and functional alterations of the brain of individuals at high risk for suicide and at low risk for suicide. We reviewed functional and structural neuroimaging studies which included individuals with a history of suicidal ideation or attempt in major depressive disorder (MDD), bipolar disorder (BD), psychosis, and borderline personality disorder (BPD). We selected 45 papers that focused on suicidality in MDD, 17 papers on BD, 11 papers on psychosis, and 5 papers on BPD. The suicidal brain across psychiatric diagnoses seems to heavily involve dysfunction of the fronto-temporal network, primarily involving reductions of gray and white matter volumes in the pre-frontal cortex (PFC), anterior cingulate, and superior temporal gyrus. Nonetheless, there are several ways to define suicidal behaviour and ideation. Therefore, it still remains difficult to combine the evidence from imaging studies that used different definitions of suicidality.
机译:脑成像是一种非侵入性和体内直接估计细节脑结构,区域脑功能和大脑分子过程的估算。本综述的主要目的是分析对自杀风险的个体功能和结构神经影像研究。我们审查了2005年至2018年之间发表的文章,在PubMed和Medline索引,评估了对自杀的高风险以及自杀风险的高风险的结构和功能改变。我们审查了功能性和结构神经影像研究,其中包括具有自杀意图或主要抑郁症(MDD),双相障碍(BD),精神病和边界人格障碍(BPD)的历史的个体。我们选择了45个论文,重点关注MDD的自杀,17篇关于BD,11篇关于精神病的论文,以及5篇关于BPD的论文。精神病诊断的自杀脑似乎严重涉及前颞网络的功能障碍,主要涉及减少前额前皮质(PFC),前铰接和优越的时间回形物中的灰色和白质量。尽管如此,有几种方法可以定义自杀行为和思想。因此,将证据与用于自由性不同定义的成像研究结合仍然难以结合起来。

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