• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Psychiatry Research. Neuroimaging >Resting regional brain activity correlates of verbal learning deficit in major depressive disorder
【24h】

Resting regional brain activity correlates of verbal learning deficit in major depressive disorder

机译：休息的区域脑活动与重大抑郁症的口头学习赤字相关联

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Memory deficits are reported in major depressive disorder (MDD). Prefrontal cortical and mesiotemporal cortical (MTC)/subcortical regions are involved in the Buschke Selective Reminding Task (SRT), a verbal list-learning task. To determine whether depression-related changes in resting brain metabolism explain (in part) the deficits in SRT performance found in MDD, statistical correlation maps were calculated between SRT total recall score (TR) and relative regional cerebral metabolic rate for glucose (rCMRglu), measured by [F-18]-flourodeoxyglucose (FDG) positron emission tomography (PET), in unmedicated, depressed MDD patients (N = 29). Subsequently, to explore hypothesized loss of top-down control in MDD, we compared the correlations between rCMRglu of SRT-relevant regions of the dorsolateral prefrontal cortex (dlPFC) and amygdala in a larger cohort of MDD (N = 60; 29 inclusive) versus healthy controls (HC) (N = 43). SRT performance of patients is on average 0.5 standard deviation below published normative mean. TR and rCMRglu positively correlate in bilateral dor-somedial PFC, d1PFC, dorsal anterior cingulate; negatively correlate in bilateral MTC/subcortical regions, and cerebellum. rCMRglu in d1PFC correlates negatively with that in amygdala in HC but not in MDD. Depression-related changes present in FDG-PET measured resting brain activity may be in part responsible for memory deficit found in MDD.
机译：在主要抑郁症（MDD）中报告了记忆缺陷。前rontal皮质和间流动脉皮质皮质（MTC）/皮质区域涉及BUSCHKE选择性提醒任务（SRT），口头列表学习任务。为了确定抑郁症与脑代谢的变化是否解释（部分）MDD中发现的SRT性能的缺陷，SRT总召回得分（TR）与葡萄糖（RCMRGLU）的相对区域脑代谢率之间计算统计相关图，通过[F-18] - 氟酸盐（FDG）正电子发射断层扫描（PET），在未抑制的MDD患者中测量（PET）测量（n = 29）。随后，为了探讨MDD中的自上而下控制的假设损失，我们将RCMRGLU与较大的MDD队列（n = 60; 29含量）与amygdala的rcmrglu之间的相关性与amygdala之间的相关性进行比较健康对照（HC）（n = 43）。患者的SRT性能平均为0.5标准偏差，低于公布的规范平均值。 TR和RCMRGLU在双侧DOR-SOMEDIAL PFC，D1PFC，背侧铰链中呈正相关;双侧MTC /皮质点区域和小脑呈负相关。 D1PFC中的RCMRGLU与HC中的Amygdala含量负相关，但不在MDD中呈负相关。 FDG-PET中存在的抑郁相关变化测量休息脑活动可能部分负责MDD中发现的内存缺陷。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号