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首页> 外文期刊>The American Journal of Tropical Medicine and Hygiene >Trends of Two Epidemic Multidrug-Resistant Strains of Mycobacterium tuberculosis in Argentina Disclosed by Tailored Molecular Strategy
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Trends of Two Epidemic Multidrug-Resistant Strains of Mycobacterium tuberculosis in Argentina Disclosed by Tailored Molecular Strategy

机译：量身定制分子策略公开了阿根廷三分枝杆菌三分枝杆菌抗性抗性抗性趋势

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摘要

Two Mycobacterium tuberculosis strains-M(sublineage 4.1) and Ra (sublineage 4.3)-have long prevailed in Argentina among patients with multidrug-resistant tuberculosis (MDR-TB). Recently, budget constraints have hampered the surveillance of MDR-TB transmission. Based on whole-genome sequence analysis, we used M- and Ra-specific single nucleotide polymorphisms to tailor two multiplex allele-specific polymerase chain reactions (PCRs), which we applied to 252 stored isolates (95% of all newly diagnosed MDR-TB cases countrywide, 2015-2017). Compared with the latest data available (2007-2009), the M strain has receded (80/324 to 20/252, P < 0.0001), particularly among cross-border migrants (12/58 to 0/53, P = 0.0003) and HIV-infected people (30/97 to 7/74, P = 0.0007), but it still accounts for 4/12 new cases of extensively drug-resistant TB. Differently, the Ra strain remained stable in frequency (39/324 to 33/252) and contributed marginally to the extensive drug-resistance load (1/12). Our novel strategy disclosed recent trends of the two major MDR-TB strains, providing meaningful data to allocate control interventions more efficiently.
机译：两种结核病菌株-M（Sublinegeage 4.1）和Ra（Sublineage 4.3） - 在耐多种抗性结核（MDR-TB）的患者中，在阿根廷中持续。最近，预算限制阻碍了MDR-TB传输的监视。基于全基因组序列分析，我们使用了M-和RA特异性单核苷酸多态性来定制两种多重等位基因特异性聚合酶链反应（PCR），我们施加到252个储存分离物（95％的新诊断的MDR-TB中Countrywide，2015-2017）。与最新数据（2007-2009）相比，M菌株已抵押（80/324至20/252，P <0.0001），特别是跨境移民（12/58至0/53，P = 0.0003）和艾滋病毒感染的人（30/97至7/74，P = 0.0007），但它仍然占4/12新耐药TB的新病例。不同，RA应变频率稳定（39/324至33/252），并略微贡献到广泛的耐药载荷（1/12）。我们的新型战略披露了近期MDR-TB毒株的最新趋势，提供了有意义的数据，以更有效地分配控制干预措施。

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