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首页> 外文期刊>The Australasian journal of dermatology >Linear IgA bullous dermatosis associated with ulcerative colitis: A case report and literature review
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Linear IgA bullous dermatosis associated with ulcerative colitis: A case report and literature review

机译：与溃疡性结肠炎相关的线性IgA大疱性皮肤病：一个案例报告和文献综述

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Abstract We report the case of a 59‐year‐old Japanese woman who developed linear IgA bullous dermatosis during treatment for ulcerative colitis that manifested as pruritic vesicles with erythema on the trunk and scalp. Histopathological examination revealed subepidermal bulla with neutrophil and eosinophil infiltration in the upper dermis. Direct immunofluorescence revealed linear IgA deposits at the basement membrane zone, and indirect immunofluorescence using split skin revealed IgA reaction to the epidermal side (lamina lucida type). We reviewed 33 reported cases of linear IgA bullous dermatosis associated with ulcerative colitis and found that ulcerative colitis preceded the onset of linear IgA bullous dermatosis in 94% of the patients and that IgA‐positive patients in split skin indirect immunofluorescence all showed the lamina lucida type, indicating that target antigens for serum IgA antibodies may reside in the lamina lucida. Regarding the pathogenetic association of ulcerative colitis and linear IgA bullous dermatosis, intestinal inflammation may induce the exposure and presentation of intestinal antigens that are cross‐reactive?to cutaneous antigens, stimulating autoimmune response to antigens of cutaneous basement membrane zones.
机译：摘要我们举报了一个59岁的日本女性的案例，在治疗过程中开发了线性IgA大疱性皮肤病，溃疡性结肠炎，表现为血管干燥和头皮上的红斑囊泡。组织病理学检查揭示了中性粒细胞和嗜酸性粒细胞浸润在上部真皮中的骨膜细胞。直接免疫荧光显示在基底膜区的线性IgA沉积物，并且使用分裂皮肤的间接免疫荧光显示对表皮侧的IgA反应（Lamina Lucida型）。我们审查了33例报告的与溃疡性结肠炎相关的线性IgA大疱性皮肤病病例，发现溃疡性结肠炎在94％的患者中的线性IgA大疱性皮肤病的发作之前，并且IgA阳性患者在分裂皮肤间接免疫荧光中都显示出薄层露潮类型，表明血清IgA抗体的靶抗原可能存在于椎板淋淋巴结中。关于溃疡性结肠炎和线性IgA大疱性皮肤病的致病性关联，肠炎可能会诱导肠抗原的暴露和呈递，所述肠抗原是交叉反应性的胃肠抗原，刺激对皮肤基底膜区域的抗原的自身免疫应答。

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