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首页> 外文期刊>The Australian and New Zealand journal of psychiatry >Finding the needle in the haystack: A review of microarray gene expression research into schizophrenia
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Finding the needle in the haystack: A review of microarray gene expression research into schizophrenia

机译：在Haystack中找到针：对精神分裂症的微阵列基因表达研究综述

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Background: With an estimated 80% heritability, molecular genetic research into schizophrenia has remained inconclusive. Recent large-scale, genome-wide association studies only identified a small number of susceptibility genes with individually very small effect sizes. However, the variable expression of the phenotype is not well captured in diagnosis-based research as well as when assuming a 'heterogenic risk model' (as apposed to a monogenic or polygenic model). Hence, the expression of susceptibility genes in response to environmental factors in concert with other disease-promoting or protecting genes has increasingly attracted attention. Method: The current review summarises findings of microarray gene expression research with relevance to schizophrenia as they emerged over the past decade. Results: Most findings from post mortem, peripheral tissues and animal models to date have linked altered gene expression in schizophrenia to presynaptic function, signalling, myelination, neural migration, cellular immune mechanisms, and response to oxidative stress consistent with multiple small effects of many individual genes. However, the majority of results are difficult to interpret due to small sample sizes (i.e. potential type-2 errors), confounding factors (i.e. medication effects) or lack of plausible neurobiological theory. Conclusion: Nevertheless, microarray gene expression research is likely to play an important role in the future when investigating gene/gene and gene/environment interactions by adopting a neurobiologically sound theoretical framework.
机译：背景：估计有80％的遗传性，分子遗传学研究进入精神分裂症仍然不确定。最近的大规模，基因组 - 范围的协会研究仅鉴定了具有单独非常小的效果大小的少量易感性基因。然而，在基于诊断的研究中，表型的可变表达在诊断的研究中并非很好地捕获，以及在假设“异丙酸风险模型”（如单一的或多种子型模型中）。因此，敏感性基因的表达响应于与其他疾病促进或保护基因的音乐会的环境因素越来越受到关注。方法：目前的审查总结了微阵列基因表达研究的结果，与精神分裂症相关，因为他们在过去十年中出现了。结果：迄今为止验尸，外周组织和动物模型的大多数发现将改变的基因表达在精神分裂症中，信号传导，髓鞘，神经迁移，细胞免疫机制以及对氧化应激的反应一致，致力于许多人的多种小效应基因。然而，由于小样本尺寸（即潜在的类型-2误差），混杂因子（即药物效应）或缺乏合理的神经生物学理论，大多数结果难以解释。结论：然而，在通过采用神经能源声音理论框架来研究基因/基因和基因/环境相互作用，微阵列基因表达研究可能在未来发挥重要作用。

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