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首页> 外文期刊>The Australian and New Zealand journal of psychiatry >Covert clozapine overdose: Clozapine toxicity in a na?ve patient
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Covert clozapine overdose: Clozapine toxicity in a na?ve patient

机译：隐蔽的氯氮平过量：氯氮平毒性在Na ve患者中

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摘要

We present a case of clozapine overdose in a patient naive to the medication. His levels are the highest reported in a patient not routinely prescribed clozapine who survived the overdose. A 68-year-old male was found collapsed and unresponsive at his front door. On arrival at the emergency department his Glasgow Coma Scale score was 5/15 (El, VI, M3). The rest of his clinical examination was unremarkable. He had no documented psychiatric history. Computerised tomography showed no acute brain injury. Toxicology indicated recent can-nabis use. A chest radiograph showed consolidation of the right lung consistent with an aspiration pneumonia.His course was notable for haemo-dynamic instability, mydriasis, multifo-cal myoclonus, ileus and fluctuating encephalopathy, and this was complicated by an aspiration pneumonia and acute kidney injury. A review of the notes showed that Emergency Medical Services personnel reported finding empty sachets of clozapine dating from 1999 in the vicinity of the patient. After 3 days, the patient's admission clozapine level came back as > 5000 nmol/L, which peaked on day 3 at 10,800 nmol/L. It later transpired that his late wife had schizophrenia and had been prescribed clozapine.
机译：我们向治疗药物幼稚的患者提供氯氮平过量的情况。他的水平是患者报告的最高报道，而不是经常在过量服用过量的氯氮藻。在他的前门被发现一个68岁的男性被发现崩溃并没有反应。抵达急诊部门，他的格拉斯哥昏迷比分是5/15（EL，VI，M3）。其余的临床检查是不起眼的。他没有记录的精神病史。计算机化断层扫描显示没有急性脑损伤。毒理学表明最近的CAN-NABIS使用。胸部射线照片显示右肺的合并肺炎肺炎.HIS课程对于血肿 - 动态不稳定性，瞳孔，莫氏菌，肌病和波动性脑病，并且受到患有肺炎和急性肾损伤的复杂性。审查报告显示，紧急医疗服务人员报告在患者附近找到从1999年的氯氮平的空皮小袋。 3天后，患者的入学氯氮平水平恢复为> 5000诺米酚/ L，在第3天达到10,800nmol / L.它后来将他的晚妻子有精神分裂症，并被规定的氯氮平。

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