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首页> 外文期刊>The Australian and New Zealand journal of psychiatry >White matter deficits in schizophrenia are global and don’t progress with age
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White matter deficits in schizophrenia are global and don’t progress with age

机译：精神分裂症的白质赤字是全球性的，并且随着年龄的增长，不行

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Introduction: Diffusion tensor imaging has revealed differences in all examined white matter tracts in schizophrenia, with a range of explanations for why this may be. The distribution and timing of differences may help explain their origin; however, results are usually dependent on the analytical method. We therefore sought to examine the extent of differences and their relationship with age using two different methods. Methods: A combined voxel-based whole-brain study and a tract-based spatial-statistics study of 104 patients with schizophrenia and 200 matched healthy controls, aged between 17 and 63?years. Results: Fractional anisotropy was reduced throughout the brain in both analyses. The relationship of fractional anisotropy with age differed between patients and controls, with controls showing the gentle fractional anisotropy decline widely noted but patients showing an essentially flat relationship: younger patients had lower fractional anisotropy than controls, but the difference disappeared with age. Mean diffusivity was widely increased in patients. Conclusion: Reduction in fractional anisotropy and increase in mean diffusivity would be consistent with global disruption in myelination; the relationship with age would suggest this is present already at the onset of their illness, but does not progress. ]]>
机译：介绍：扩散张量成像在精神分裂症中的所有检查的白质暗影中揭示了差异，为什么这可能是一系列解释。分配和差异的时间可能有助于解释他们的起源;但是，结果通常取决于分析方法。因此，我们试图使用两种不同的方法来研究差异的程度及其与年龄的关系。方法：基于体素的全脑研究和104例精神分裂症患者的血清型血清统计研究和200名匹配的健康对照组，年龄在17至63岁以下。结果：分析中整个大脑中的分数各向异性降低。患者和对照组分数各向异性的关系，对照有患者均广泛指出的柔和分数各向异性下降，但患者显示基本平坦的关系：年轻患者的分数各向异性较低，但差异随着年龄的增长而消失。患者的平均扩散性广泛增加。结论：减少分数各向异性，平均扩散率的增加将与髓鞘中的全球破坏一致;与年龄的关系建议这是在他们疾病的开始存在的情况下存在，但没有进展。 ]]>

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