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首页> 外文期刊>The Australian and New Zealand journal of psychiatry >Comparison of neuropsychological functioning and emotional processing in major depression and social anxiety disorder subjects, and matched healthy controls.
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Comparison of neuropsychological functioning and emotional processing in major depression and social anxiety disorder subjects, and matched healthy controls.

机译:主要抑郁症和社会焦虑障碍受试者中神经心理功能和情绪加工的比较,匹配健康对照。

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Objectives: Few studies of neuropsychological function in major depression have examined emotional processing or the impact of gender. Patients have also been compared with highly selected control participants and rarely with other patient groups. The objective of this study was to compare neuropsychological function in a major depressive episode (MDE) with a group of patients with an anxiety disorder, social anxiety disorder (SAD), and healthy controls, to include measures of emotional processing and to analyse the effects of gender on neuropsychological function and emotional processing in these groups. Method: One hundred and one medication-free patients with MDE, 30 patients with SAD and 76 healthy control participants were recruited. The groups were matched for age and estimated premorbid intelligence and education. Subjects performed a battery of neuropsychological tests assessing; verbal learning and memory, visuospatial learning and memory, attention, executive function and psychomotor performance. They also performed a task measuring the accuracy of recognition of facial emotional expressions. Results: Compared with healthy participants and those with SAD, patients with MDE were significantly impaired in verbal learning and spatial working memory. The SAD group misclassified significantly more neutral expressions as angry and fewer as sad, compared with the MDE group and healthy controls, but there were no significant differences between the MDE group and healthy controls. The profile of performance was the same regardless of gender. Conclusions: The study confirms a significant impairment in neuropsychological function in a clinical sample of outpatients with MDE, which is likely to have important implications for day-to-day functioning and treatment.
机译:目的:少数关于主要抑郁症神经心理功能的研究已经检查了情绪加工或性别的影响。患者也与高度选择的对照参与者进行了比较,并且很少与其他患者组相比。本研究的目的是将神经心理功能与一群焦虑症,社交焦虑症(悲伤)和健康控制的患者进行比较,包括情绪处理的措施并分析效果这些群体中神经心理功能和情感加工的性别。方法:招募了一百一左右的免药患者,招募了30名悲伤和76名健康控制参与者。该群体符合年龄和估计的预血基智力和教育。受试者进行了一种神经心理学测试评估的电池;言语学习和记忆,探索学习和记忆,关注,执行功能和精神运动的性能。他们还执行了测量面部情感表达的识别准确性的任务。结果:与健康参与者和悲伤的人相比,MDE患者在口头学习和空间工作记忆中显着受损。与MDE组和健康对照组相比,悲伤的群体被错误分类为愤怒和较少的悲伤,令人悲伤的更少,但MDE组和健康控制之间没有显着差异。无论性别如何,性能的概况都是相同的。结论:该研究证实了在患有MDE的门诊患者临床外临床样本中的神经心理功能的显着损害,这可能对日常功能和治疗具有重要意义。

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