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首页> 外文期刊>The British journal of psychiatry : >The role of prenatal stress as a pathway to personality disorder: longitudinal birth cohort study
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The role of prenatal stress as a pathway to personality disorder: longitudinal birth cohort study

机译：产前压力作为人格障碍途径的作用：纵向出生队列研究

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Background Many studies have reported associations between prenatal stress and the development of psychotic, anxiety and depressive disorders; however, to date no studies have investigated potential associations with personality disorders. Aims This study investigated potential associations between exposure to prenatal stress and personality disorder in offspring. Method In a subsample (N = 3626) of a large Finnish birth cohort, we used logistic regression models to examine associations between self-reported maternal stress during pregnancy, collected monthly during antenatal clinic appointments, and personality disorder in offspring. Familial and outcome information were obtained by linking data from the Finnish Hospital Discharge Register and the Finnish Population Register. Results Compared with those unexposed, children exposed to any maternal stress during gestation had three times the odds of developing a personality disorder (odds ratio 3.28, 95% CI 1.75-6.15, P < 0.0001). Those exposed to moderate stress had three times the odds (odds ratio 3.13, 95% CI 1.42-6.88, P = 0.005) and those exposed to severe stress had seven times the odds (odds ratio 7.02, 95% CI 2.08-23.66, P = 0.002) of developing a personality disorder. These associations remained after adjusting for parental psychiatric history, comorbid psychiatric diagnoses, prenatal smoking and antenatal depression. Conclusions Exposure to stress during gestation increases the odds of personality disorder in offspring, independent of other psychiatric disorders. These results suggest the assessment of maternal stress and well-being during pregnancy may be useful in identifying those at greatest risk of developing personality disorder, and highlight the importance of prenatal care for good maternal mental health during pregnancy.
机译：背景技术许多研究报告了产前压力与精神病，焦虑和抑郁症的发展之间的关联;但是，迄今为止，没有研究调查了与人格障碍的潜在关联。目的本研究调查了在后代暴露于产前压力和人格障碍之间的潜在关联。在大型芬兰出生队列的子样本（n = 3626）中的方法，我们使用了逻辑回归模型来检查怀孕期间自我报告的母体应激之间的关联，在产前诊所预约期间收集，后代人格障碍。通过将数据与芬兰医院放电登记册和芬兰人口登记册联系起来获得了家庭和结果信息。结果与未曝光的人相比，妊娠中的任何母体压力暴露的儿童有三倍的发展人格障碍的几率（差距3.28,95％CI 1.75-61.15，P <0.0001）。暴露于中度应激的人有三倍的赔率（大量比率3.13,95％CI 1.42-6.88，p = 0.005），暴露于严重应激的人具有七倍的赔率（差距7.02,95％Ci 2.08-23.66，P = 0.002）发展人格障碍。这些协会在调整父母精神病史，合并症精神病诊断，产前吸烟和产前抑制后仍然存在。结论在妊娠期间暴露于压力会增加后代人格障碍的几率，独立于其他精神疾病。这些结果表明，孕产妇压力和孕期性的评估可能有助于鉴定最大的发展人格障碍风险，并突出怀孕期间孕产妇心理健康的产前护理的重要性。

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