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首页> 外文期刊>The British journal of psychiatry : >Associations between schizophrenia genetic risk, anxiety disorders and manic/hypomanic episode in a longitudinal population cohort study
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Associations between schizophrenia genetic risk, anxiety disorders and manic/hypomanic episode in a longitudinal population cohort study

机译：精神分裂症遗传风险，焦虑障碍和躁狂/疥疮的协会在纵向人口队列研究中

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Background Studies involving clinically recruited samples show that genetic liability to schizophrenia overlaps with that for several psychiatric disorders including bipolar disorder, major depression and, in a population study, anxiety disorder and negative symptoms in adolescence. Aims We examined whether, at a population level, association between schizophrenia liability and anxiety disorders continues into adulthood, for specific anxiety disorders and as a group. We explored in an epidemiologically based cohort the nature of adult psychopathology sharing liability to schizophrenia. Method Schizophrenia polygenic risk scores (PRSs) were calculated for 590 European-descent individuals from the Christchurch Health and Development Study. Logistic regression was used to examine associations between schizophrenia PRS and four anxiety disorders (social phobia, specific phobia, panic disorder and generalised anxiety disorder), schizophrenia/schizophreniform disorder, manic/hypomanic episode, alcohol dependence, major depression, and - using linear regression - total number of anxiety disorders. A novel population-level association with hypomania was tested in a UK birth cohort (Avon Longitudinal Study of Parents and Children). Results Schizophrenia PRS was associated with total number of anxiety disorders and with generalised anxiety disorder and panic disorder. We show a novel population-level association between schizophrenia PRS and manic/hypomanic episode. Conclusions The relationship between schizophrenia liability and anxiety disorders is not restricted to psychopathology in adolescence but is present in adulthood and specifically linked to generalised anxiety disorder and panic disorder. We suggest that the association between schizophrenia liability and hypomanic/manic episodes found in clinical samples may not be due to bias.
机译：背景技术涉及临床招募的样本表明，遗传责任与精神分裂症重叠，其几种精神病疾病，包括双相情感障碍，主要抑郁症，以及在人口研究中，焦虑症和青春期的阴性症状。目的我们研究了在人口层面，精神分裂症责任和焦虑症之间的关联是否持续到已成年期，针对特异性焦虑症和作为一组。我们在流行病学队伍中探讨了成人精神病理学分担对精神分裂症的责任的性质。方法从基督城卫生和开发研究中计算精神分裂症多基因风险评分（PRS）为590名欧洲下降。逻辑回归用于检查精神分裂症治疗和四种焦虑症的关联（社交恐惧症，特异性恐惧症，恐慌障碍和广泛性焦虑症），精神分裂症/精神分裂症疾病，躁狂/疥疮发作，酒精依赖性，重症抑郁和 - 使用线性回归 - 焦虑症的总数。在英国出生队列（父母和儿童的AVON纵向研究）中测试了一种与Hypomania的新型人口水平联系。结果精神分裂症与焦虑症的总数和广泛的焦虑症和恐慌症有关。我们展示了精神分裂症PRS和狂躁/疥疮发作之间的新型人口级联系。结论精神分裂症责任与焦虑症之间的关系不仅限于青春期的精神病理学，但在成年期呈现，与广义焦虑症和恐慌症有关。我们建议在临床样本中发现的精神分裂症责任和疥疮/躁狂事件之间的关联可能不是由于偏差。

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