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首页> 外文期刊>The European Journal of Neuroscience >Effects of oxytocin-family peptides and substance P on locomotor activity and filial preferences in visually naive chicks
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Effects of oxytocin-family peptides and substance P on locomotor activity and filial preferences in visually naive chicks

机译：催产素 - 家庭肽和物质P对视觉幼稚小鸡在运动活性和孝道偏好的影响

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Nonapeptides from the vasopressin/oxytocin family have been implicated in a wide variety of social behaviours across vertebrates. Experimental manipulations that alter nonapeptide levels or receptor function in the brain have provided evidence for understanding how nonapeptides influence responses to social stimuli in adults. While behaviours in adults have been extensively studied, much less in known about roles of nonapeptides in early life and the development of affiliative social behaviours. We examined an experience-independent preference (social predisposition) that is present at hatching and is characterized by the tendency of visually naive chicks (Gallus gallus) to prefer to approach a stuffed hen stimulus over a control stimulus in a choice test. Among chicks that show the social predisposition preference, bilateral intracranial mesotocin injections resulted in higher mean hen preference scores compared with saline-injected controls. Equimolar doses of mesotocin and vasotocin injections had different effects on locomotor activity: vasotocin, but not mesotocin, resulted in hypoactivity. We also tested whether intraperitoneal substance P had an effect on hen preference scores because previous research has proposed that vasotocin effects on social approach are mediated by peripheral release of substance P, but found no significant effect. All together, our data suggest that mesotocin signalling may be important for social predispositions and can potentially enhance the perceived salience of social stimuli soon after hatching. Specifically, mesotocin release and signalling in the brain may regulate the ability to recognize naturalistic stimuli and/or to act on the motivation to approach naturalistic stimuli.
机译：来自血管加压素/催产素家族的非肽在脊椎动物上涉及各种各样的社会行为。在大脑中改变非肽水平或受体功能的实验性操纵已经提供了了解非肽如何影响成人对社会刺激的反应。虽然成年人的行为被广泛研究，但在早期生命和隶属于社会行为的发展中，众所周知。我们研究了一个独立于孵化的体验 - 独立的偏好（社会易感性），其特征在于视觉幼稚雏鸡（巨大巨大），优选在选择试验中对控制刺激接近填充母鸡刺激。在表现出社会易感偏好的雏鸡中，与盐水注入的对照相比，双侧颅内间胚胎注射液导致更高的平均母鸡偏好分数。 Equimolar剂量的MesoTocin和血管谱注射对运动活性产生不同的影响：血管谱，但不是中塞霉素，导致脱氧性。我们还测试了腹膜内物质P是否对母鸡偏好分数产生影响，因为之前的研究提出了血管谱对社会方法的影响是由物质P的外周释放介导的，但发现没有显着效果。一切都在一起，我们的数据表明，Mesotocin信号对社会倾向可能是重要的，并且在孵化后可能会很快提高社会刺激的显着性。具体而言，脑中的间孔释放和信号在大脑中可能会调节识别自然刺激和/或采取行动以接近自然刺激的动机的能力。

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