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首页> 外文期刊>The European Journal of Neuroscience >Cognitive functioning in glioma patients is related to functional connectivity measures of the non-tumoural hemisphere
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Cognitive functioning in glioma patients is related to functional connectivity measures of the non-tumoural hemisphere

机译：胶质瘤患者的认知功能与非巨大半球的功能性连体措施有关

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Previous studies have shown that cognitive functioning in patients with brain tumour is associated with the functional network characteristics of specific resting-state networks or with whole-brain network characteristics. These studies, however, did not acknowledge the functional contribution of areas in the contralesional, non-tumoural hemisphere, even though these healthy remote areas likely play a critical role in compensating for the loss of function in damaged tissue. In the current study, we examined whether there is an association between cognitive performance and functional network features of the contralesional hemisphere of patients with glioma. We found that local efficiency of the contralesional hemisphere was associated with performance on the reaction time domain, whereas contralesional assortativity was associated with complex attention and cognitive flexibility scores. Our results suggest that a less segregated organization of the contralesional hemisphere is associated with better reaction time scores, whereas a better spread of information over the contralesional hemisphere through mutually interconnected contralesional hubs is associated with better cognitive flexibility and better complex attention scores. These findings urge researchers to recognize the functional contribution of remote, undamaged regions and to focus more on the graph metrics of the contralesional hemisphere in the search for predictors of cognitive functioning in patients with brain tumour.
机译：以前的研究表明，脑肿瘤患者的认知功能与特定休息状态网络的功能网络特征或全脑网络特征有关。然而，这些研究并未承认相对，非巨大半球区域的功能贡献，即使这些健康的偏远地区可能在补偿受损组织中的功能丧失时发挥着关键作用。在目前的研究中，我们检查了胶质瘤患者对照半球的认知性能和功能网络特征之间是否存在关联。我们发现，局部效率与反应时域的性能相关，而对照assortisivity与复杂的关注和认知灵活性分数相关。我们的研究结果表明，禁区半球的较少分离组织与更好的反应时间分数相关，而通过相互互连的对立集线器更好地传播相互联系的对侧枢纽与更好的认知灵活性和更好的复杂关注分数相关。这些调查结果敦促研究人员认识到遥控，未损坏的区域的功能贡献，并更多地关注脑肿瘤患者的认知功能的预测因子的跳动半球的图表度量。

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